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Publications
Year 2022
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Xu, X., Chew, K. A., Wong, Z. X., Phua, A. K. S., Chong, E. J. Y., Teo, C. K. L., ... & Chen, C. L. H. (2022). The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol. The Journal of Prevention of Alzheimer's Disease, 1-9.
DOI: 10.14283/jpad.2022.5
Egle, M., Hilal, S., Tuladhar, A. M., Pirpamer, L., Hofer, E., Duering, M., ... & Markus, H. S. (2022). Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration. Journal of Neurology, Neurosurgery & Psychiatry, 93(1), 14-23.
DOI: 10.1136/jnnp-2021-326571
Tanaka, T., Gyanwali, B., Villaraza, S. G., Saridin, F. N., Vrooman, H., Ihara, M., ... & Hilal, S. (2022). The Association Between Standard Electrocardiography and Cerebral Small Vessel Disease in a Memory Clinic Study. Journal of Alzheimer's Disease, (Preprint), 1-13.
DOI: 10.3233/JAD-215413
Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H. J., Lim, J. S., Godefroy, O., ... & Stroke and Cognition (STROKOG) Collaboration. (2022). Long-Term Cognitive Decline After Stroke: An Individual Participant Data Meta-Analysis. Stroke.
DOI: 10.1161/STROKEAHA.121.035796
Tan, H. K., Narasimhalu, K., Ting, S. K. S., Hameed, S., Chang, H. M., De Silva, D. A., ... & Tan, E. K. (2022). B-vitamin supplementation on mitigating post-stroke cognition and neuropsychiatric sequelae: A randomized controlled trial. International Journal of Stroke.
DOI: 10.1177/17474930221085880
Hampel, H., Vergallo, A., Iwatsubo, T., Cho, M., Kurokawa, K., Wang, H., ... & Chen, C. (2022). Evaluation of major national dementia policies and health‐care system preparedness for early medical action and implementation. Alzheimer's & Dementia.
DOI: 10.1002/alz.12655
Chen, C. L., Lu, Q., Moorakonda, R. B., Kandiah, N., Tan, B. Y., Villaraza, S. G., ... & Venketasubramanian, N. (2022). Alzheimer's Disease THErapy With NEuroaid (ATHENE): A Randomized Double-Blind Delayed-Start Trial. Journal of the American Medical Directors Association, 23(3), 379-386.
DOI: 10.1016/j.jamda.2021.10.018
Beaman, C., Kozii, K., Hilal, S., Liu, M., Spagnolo-Allende, A. J., Polanco-Serra, G., ... & Gutierrez, J. (2022). Cerebral Microbleeds, Cerebral Amyloid Angiopathy, and Their Relationships to Quantitative Markers of Neurodegeneration. Neurology.
DOI: 10.1212/WNL.0000000000200142
Ferro, D. A., Kuijf, H. J., Hilal, S., van Veluw, S. J., van Veldhuizen, D., Venketasubramanian, N., ... & Chen, C. (2022). Association Between Cerebral Cortical Microinfarcts and Perilesional Cortical Atrophy on 3T MRI. Neurology, 98 (6).
DOI: 10.1212/WNL.0000000000013140
Rajeev, V., Fann, D. Y., Dinh, Q. N., Kim, H. A., De Silva, T. M., Lai, M. K., ... & Arumugam, T. V. (2022). Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment. Theranostics, 12(4), 1639.
DOI: 10.7150/thno.68304
Poh, L., Sim, W. L., Jo, D. G., Dinh, Q. N., Drummond, G. R., Sobey, C. G., ... & Arumugam, T. V. (2022). The role of inflammasomes in vascular cognitive impairment. Molecular neurodegeneration, 17(1), 1-28.
DOI: 10.1186/s13024-021-00506-8
Anderson, C. S., Rodgers, A., De Silva, H. A., Martins, S. O., Klijn, C. J., Senanayake, B., ... & Chalmers, J. (2022). Triple Therapy Prevention of Recurrent Intracerebral Disease Events Trial: Rationale, design and progress. International Journal of Stroke.
DOI: 10.1177/17474930211068671
Hampel, H., Shaw, L. M., Aisen, P., Chen, C., Lleó, A., Iwatsubo, T., ... & Vergallo, A. (2022). State‐of‐the‐art of lumbar puncture and its place in the journey of patients with Alzheimer's disease. Alzheimer's & Dementia, 18(1), 159-177.
DOI: 10.1002/alz.12372
Kan, C. N., Xu, X., Schmetterer, L., Venketasubramanian, N., Chen, C., & Tan, C. H. (2022). Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition. Neurobiology of aging, 109, 239-246.
DOI: 10.1016/j.neurobiolaging.2021.10.008
Year 2021
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Zhang, L., Biessels, G. J., Hilal, S., Chong, J. S. X., Liu, S., Shim, H. Y., Xu X., Chong E. J. Y., Wong Z. X., Loke Y. M., Venketasubramaniam N., Tan B. Y., Chen C. L. H., & Zhou, J. H. (2021). Cerebral microinfarcts affect brain structural network topology in cognitively impaired patients. Journal of Cerebral Blood Flow & Metabolism, 41(1), 105-115.
DOI: 10.1177/0271678X20902187
Kandiah, N., Chan, Y. F., Chen, C., Dasig, D., Dominguez, J., Han, S. H., Jia J., Kim S., Limpawattana P., Ng L. L., Nguyen D. T., Ong P. A., Raya-Ampil E., Saedon N., Senanarong V., Setiati S., Singh H., Suthisisang C., Trang T. M., Turana Y., Venketasubramanian N., Yong F. M., Youn Y. C., & Ihl, R. (2020). Strategies for the use of Ginkgo biloba extract, EGb 761®, in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neuroscience & Therapeutics.
DOI: 10.1111/cns.13536
Lam, B. W. S., Yam, T. Y. A., Chen, C. P., Lai, M. K., Ong, W. Y., & Herr, D. R. (2021). The noncanonical chronicles: Emerging roles of sphingolipid structural variants. Cellular Signalling, 79, 109-890.
DOI: 10.1016/j.cellsig.2020.109890
Liu, H., Nai, Y. H., Saridin, F., Tanaka, T., O’Doherty, J., Hilal, S., Gyanwali, B., Chen, C. P., Robins, E. G., & Reilhac, A. Improved amyloid burden quantification with nonspecific estimates using deep learning. European Journal of Nuclear Medicine and Molecular Imaging, 1-12
DOI: 10.1007/s00259-020-05131-z
Hilal, S., Mutsaerts, H. J., Ferro, D. A., Petr, J., Kuijf, H. J., Biessels, G. J., & Chen, C. The Effects of Intracranial Stenosis on Cerebral Perfusion and Cognitive Performance. Journal of Alzheimer's Disease, (Preprint), 1-12.
DOI: 10.3233/JAD-201131
Fenwick, E. K., Gan, A. T., Man, R. E., Gupta, P., Sabanayagam, C., Cheng, C. Y., Chen, C. L., Cheung, C. Y., Wong, K. H., Venketasubramanian, N., Xu, X., Hilal, S., Chong, E. J. Y., Tham, Y. C., Wong, T. Y., & Lamoureux, E. L. (2021). Vision, vision-specific functioning and mobility, and their relationship with clinically assessed cognitive impairment. Age and Ageing.
DOI: 10.1016/j.amjoto.2019.102377
Best, J. G., Ambler, G., Wilson, D., Lee, K. J., Lim, J. S., Shiozawa, M., ... & Marsh, R. (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. The Lancet Neurology, 20(4), 294-303.
DOI: 10.1016/S1474-4422(21)00024-7
Chai, Y. L., Chong, J. R., Raquib, A. R., Xu, X., Hilal, S., Venketasubramanian, N., ... & Lai, M. K. (2021). Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment. Scientific reports, 11(1), 1-11.
DOI: 10.1038/s41598-021-83601-6
Tanaka, T., Ruifen, J. C., Nai, Y. H., Tan, C. H., Lim, C. Z., Zhang, Y., ... & Chen, C. (2021). Head‐to‐head comparison of amplified plasmonic exosome Aβ42 platform and single‐molecule array immunoassay in a memory clinic cohort. European journal of neurology, 28(5), 1479-1489.
DOI: 10.1111/ene.14704
Xu, X., Ni Kan, C., Li-Hsian Chen, C., & Hilal, S. (2021). Long-term neurobehavioral correlates of brain cortical microinfarcts in a memory clinic cohort in Singapore. International Journal of Stroke, 17474930211006294.
DOI: 10.1177/17474930211006294
Lim, M. J. R., Tan, C. S., Gyanwali, B., Chen, C., & Hilal, S. (2021). The effect of intracranial stenosis on cognitive decline in a memory clinic cohort. European Journal of Neurology.
DOI: 10.1111/ene.14788
Shim, Y. S., Park, K. H., Chen, C., Dominguez, J. C., Kang, K., Kim, H. J., ... & Kim, S. (2021). Caregiving, care burden and awareness of caregivers and patients with dementia in Asian locations: a secondary analysis. BMC geriatrics, 21(1), 1-10.
DOI: 10.1186/s12877-021-02178-x
Chua, X.Y., Ho, L.T.Y., Xiang, P. et al. Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromol Med 23, 47–67 (2021).
DOI: 10.1007/s12017-020-08632-0
Hilal, S., Liu, S., Wong, T. Y., Vrooman, H., Cheng, C. Y., Venketasubramanian, N., ... & Zhou, J. H. (2021). White matter network damage mediates association between cerebrovascular disease and cognition. Journal of Cerebral Blood Flow & Metabolism, 0271678X21990980.
DOI: 10.1177/0271678X21990980
Chew, K. A., Xu, X., Siongco, P., Villaraza, S., Phua, A. K. S., Wong, Z. X., ... & Chen, C. (2021). SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)–pilot: A feasibility study. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), e12141.
DOI: 10.1002/trc2.12141
Chong, J. R., Ashton, N. J., Karikari, T. K., Tanaka, T., Saridin, F. N., Reilhac, A., ... & Chen, C. P. (2021). Plasma P‐tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease. Alzheimer's & Dementia.
DOI: 10.1002/alz.12332
Chen, C. L., Nguyen, T. H., Marasigan, S., Lee, C. F., Lu, Q., Kandiah, N., ... & Venketasubramanian, N. (2021). NEURoaid II (MLC901) in cognitively Impaired not demenTEd patientS (NEURITES): A pilot double blind, placebo‐controlled randomized trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), e12161.
DOI: 10.1002/trc2.12161
Weaver, N. A., Kuijf, H. J., Aben, H. P., Abrigo, J., Bae, H. J., Barbay, M., ... & Biessels, G. J. (2021). Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. The Lancet Neurology, 20(6), 448-459.
DOI: 10.1016/S1474-4422(21)00060-0
Gyanwali, B., Lai, M. K., Lui, B., Liew, O. W., Venketasubramanian, N., Richards, A. M., ... & Hilal, S. (2021). Blood-Based Cardiac Biomarkers and the Risk of Cognitive Decline, Cerebrovascular Disease, and Clinical Events. Stroke, STROKEAHA-120.
DOI: 10.1161/STROKEAHA.120.032571
Gyanwali, B., Xue Ting Cai, C., Chen, C., Vrooman, H., Tan, C. S., & Hilal, S. The Effects of Mean of Visit-to-Visit Blood Pressure on Incident Brain Vascular Lesions and Functional-Cognitive Decline. Journal of Alzheimer's Disease, (Preprint), 1-12.
DOI: 10.3233/JAD-210188
Hilal, S., Biesbroek, J. M., Vrooman, H., Chong, E., Kuijf, H. J., Venketasubramanian, N., ... & Chen, C. (2021). The impact of strategic white matter hyperintensity lesion location on language. The American Journal of Geriatric Psychiatry, 29(2), 156-165.
DOI: 10.1016/j.jagp.2020.06.009
Wu, L. Y., Cheah, I. K., Chong, J. R., Chai, Y. L., Tan, J. Y., Hilal, S., ... & Lai, M. K. (2021). Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia. Free Radical Biology and Medicine, 177, 201-211.
DOI: 10.1016/j.freeradbiomed.2021.10.019
Poh, L., Razak, S. M. B. A., Lim, H. M., Lai, M. K., Chen, C. L. H., Lim, L. H., ... & Fann, D. Y. (2021). AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusion. Experimental Neurology, 346, 113856.
DOI: 10.1016/j.expneurol.2021.113856
de Brito Robalo, B. M., Biessels, G. J., Chen, C., Dewenter, A., Duering, M., Hilal, S., ... & de Luca, A. (2021). Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease. NeuroImage: Clinical, 32, 102886.
DOI: 10.1016/j.nicl.2021.102886
Chen, C. L., & Rundek, T. (2021). Vascular Brain Health. Stroke, 52(11), 3700-3705.
DOI: 10.1161/STROKEAHA.121.033450
Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., ... & Vergallo, A. (2021). The amyloid-β pathway in alzheimer’s disease. Molecular psychiatry, 1-23.
DOI: 10.1038/s41380-021-01249-0
Zhao, X., Chong, E. J. Y., Qi, W., Pang, T., Xu, X., & Chen, C. (2021). Domain-Specific Cognitive Trajectories Among Patients with Minor Stroke or Transient Ischemic Attack in a 6-Year Prospective Asian Cohort: Serial Patterns and Indicators. Journal of Alzheimer's Disease, 83(2), 557-568.
10.3233/JAD-210619
Chong, J. R., Ashton, N. J., Karikari, T. K., Tanaka, T., Schöll, M., Zetterberg, H., ... & Lai, M. K. (2021). Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer’s disease: a focused review on recent advances. Journal of Neurology, Neurosurgery & Psychiatry, 92(11), 1231-1241.
DOI: 10.1136/jnnp-2021-327370
Rojer, A. G., Ramsey, K. A., Gomes, E. S. A., D’Andrea, L., Chen, C., Szoeke, C., ... & Maier, A. B. (2021). Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review. Mechanisms of ageing and development, 198, 111524.
DOI: 10.1016/j.mad.2021.111524
Poh, L., Rajeev, V., Selvaraji, S., Lai, M. K., Chen, C. L. H., Arumugam, T. V., & Fann, D. Y. (2021). Intermittent fasting attenuates inflammasome-associated apoptotic and pyroptotic death in the brain following chronic hypoperfusion. Neurochemistry International, 148, 105109.
DOI: 10.1016/j.neuint.2021.105109
Yuen, V., Ran, A., Shi, J., Sham, K., Yang, D., Chan, V. T., ... & Cheung, C. Y. (2021). Deep-Learning–Based Pre-Diagnosis Assessment Module for Retinal Photographs: A Multicenter Study. Translational vision science & technology, 10(11), 16-16.
DOi: 10.1167/tvst.10.11.16
Gyanwali, B., Lui, B., Tan, C. S., Chong, E. J., Vrooman, H., Chen, C., & Hilal, S. (2021). Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study. Current Alzheimer Research, 18(5), 399-413.
DOI: 10.2174/1567205018666210820125543
Truong, A. T., Tan, L. W., Chew, K. A., Villaraza, S., Siongco, P., Blasiak, A., ... & Ho, D. (2021). Harnessing CURATE. AI for N‐of‐1 Optimization Analysis of Combination Therapy in Hypertension Patients: A Retrospective Case Series. Advanced Therapeutics, 4(10), 2100091.
DOI: 10.1002/adtp.202100091
Vu, T. A., Fenwick, E. K., Gan, A. T., Man, R. E., Tan, B. K., Gupta, P., ... & Lamoureux, E. L. (2021). The bidirectional relationship between vision and cognition: a systematic review and meta-analysis. Ophthalmology, 128(7), 981-992.
DOI: 10.1016/j.ophtha.2020.12.010
Park, K. H., Yang, Y., Chen, C., Shim, Y. S., Domingueze, J. C., Lee, C. N., ... & Kim, S. (2021). Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia. Journal of clinical neurology (Seoul, Korea), 17(3), 376.
DOi: 10.3988/jcn.2021.17.3.376
Baik, S. H., Selvaraji, S., Fann, D. Y., Poh, L., Jo, D. G., Herr, D. R., ... & Arumugam, T. V. (2021). Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging. Aging (Albany NY), 13(11), 14651.
DOI: 10.18632/aging.203123
Cheung, C. Y., Mok, V., Foster, P. J., Trucco, E., Chen, C., & Wong, T. Y. (2021). Retinal imaging in Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 92(9), 983-994.
DOI: 10.1136/jnnp-2020-325347
Lam, B. Y. K., Yiu, B., Ampil, E., Chen, C. L. H., Dikot, Y., Dominguez, J. C., ... & Mok, V. C. T. (2021). High burden of cerebral white matter lesion in 9 Asian cities. Scientific reports, 11(1), 1-12.
DOI: 10.1038/s41598-021-90746-x
Year 2020
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Chen, Y., & Chen, C. (2020). How to support the quality of life of people living with cognitive disorders: a (k) new challenge in the post‐COVID‐19 world. European Journal of Neurology, 27(9), 1742-1743.
DOI: 10.1111/ene.143730
Akiba, C., Gyanwali, B., Villaraza, S., Nakajima, M., Miyajima, M., Cheng, C. Y., Wong, T. Y., Venketasubramanian, N., Hilal, S., & Chen, C. (2020). The prevalence and clinical associations of Disproportionately Enlarged Subarachnoid Space Hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts. Journal of the Neurological Sciences, 408, 116-510.
DOI: 10.1016/j.jns.2019.116510
Ferro, D. A., Mutsaerts, H. J., Hilal, S., Kuijf, H. J., Petersen, E. T., Petr, J., van Veluw, S. J., Venketasubramanian, N., Boon Yeow, T., Jan Biessels, G., & Chen, C. (2020). Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion. Journal of Cerebral Blood Flow & Metabolism, 40(9), 1869-1878.
DOI: 10.1177/0271678X19877403
Yassi, N., Hilal, S., Xia, Y., Lim, Y. Y., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P. M., & Masters, C. L. (2020). Influence of comorbidity of cerebrovascular disease and amyloid-β on Alzheimer’s disease. Journal of Alzheimer's Disease, 73(3), 897-907.
DOI: 10.3233/JAD-191028
Kivipelto, M., Mangialasche, F., Snyder, H. M., Allegri, R., Andrieu, S., Arai, H., Baker, L., Belleville, S., Brodaty, H., Brucki, S. M., Calandri, I., Caramelli, P., Chen, C., Chertkow, H., Chew, E., Choi, S. H., Chowdhary, N., Crivelli, L., Torre, R., Du, Y., Dua, T., Espeland, M., Feldman, H. H., Hartmanis, M., Hartmann, T., Heffernan, M., Henry, C. J., Hong, C. H., Håkansson, K., Iwatsubo, T., Jeong, J. H., Jimenez-Maggiora, G., Koo, E. H., Launer, L. J., Lehtisalo, J., Lopera, F., Martínez-Lage, P., Martins, R., Middleton, L., Molinuevo, J. L., Montero-Odasso, M., Moon, S. Y., Morales-Pérez, K., Nitrini, R., Nygaard, H. B., Park, Y. K., Peltonen, M., Qiu, C., Quiroz, Y. T., Raman, R., Rao, N., Ravindranath, V., Rosenberg, A., Sakurai, T., Salinas, R. M., Scheltens, P., Sevlever, G., Soininen, H., Sosa, A. L., Suemoto, C. K., Tainta-Cuezva, M., Velilla, L., Wang, Y., Whitmer, R., Xu, X., Bain, L. J., Solomon, A., Ngandu, T., & Carrillo, M. C. (2020). World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimer's & Dementia, 16(7), 1078-1094.
DOI: 10.1002/alz.12123
Hilal, S., Tan, C. S., van Veluw, S. J., Xu, X., Vrooman, H., Tan, B. Y., Venketasubramanian, N., Biessels, G. J., & Chen, C. (2020). Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients. Journal of Cerebral Blood Flow & Metabolism, 40(1), 44-53.
DOI: 10.1177/0271678X19835565
Zhang, L., Zuo, X. N., Ng, K. K., Chong, J. S. X., Shim, H. Y., Ong, M. Q. W., Loke, Y. M., Choo, B. L., Chong, E. J. Y., Wong, Z. X., Hilal, S., Venketasubramanian, N., Tan, B. Y., Chen, C. L., & Zhou, J. H. (2020). Distinct BOLD variability changes in the default mode and salience networks in Alzheimer’s disease spectrum and associations with cognitive decline. Scientific Reports, 10(1), 1-12.
DOI: 10.1038/s41598-020-63540-4
Lim, Z. W., Chee, M. L., Da Soh, Z., Cheung, N., Dai, W., Sahil, T. Tao, Y., Majithia, S., Sabanayagam, C., Chen, C. L., Wong, T. Y., Cheng, C. Y., & Tham, Y. C. (2020). Association between visual impairment and decline in cognitive function in a multiethnic Asian population. JAMA Network Open, 3(4), e203560-e203560.
DOI: 10.1001/jamanetworkopen.2020.3560
Ng, S. S., Park, J. E., Meng, W., Chen, C. P., Kalaria, R. N., McCarthy, N. E., & Sze, S. K. (2020). Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation. ACS Omega, 5(23), 13528-13540.
DOI: 10.1021/acsomega.9b04439
Chew, K. A., Chong, E. J., Chen, C. L. & Xu, X. (2020). Psychometric Properties of the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network Neuropsychological Battery in an Asian Older Adult Sample. Journal of the American Medical Directors Association, 21(6), 879-883.
DOI: 10.1016/j.jamda.2020.03.022
Chua, X. Y., Chai, Y. L., Chew, W. S., Chong, J. R., Ang, H. L., Xiang, P., Camara, K., Howell, A. R., Torta, F., Wenk, M. R., Hilal, S., Venketasubramanian, N., Chen, C. P., Herr, D. R., & Lai, M. K. P. (2020). Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment. Alzheimer's Research & Therapy, 12(1), 1-12.
DOI: 10.1186/s13195-020-00694-3
Zhang, L., Mak, E., Reilhac, A., Shim, H. Y., Ng, K. K., Ong, M. Q. W., Ji, F., Chong, E., Xu, X., Wong, Z. X., Stephenson, M. C., Venketasubramaniam, N., Tan, B. Y., O’Brien, J., Zhou, H. J., Chen, C., & Alzheimer's Disease Neuroimaging Initiative. (2020). Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in non-demented elderly. Human Brain Mapping, 41(8), 2037-2047.
DOI: 10.1002/hbm.24928
Tanaka, T., Stephenson, M. C., Nai, Y. H., Khor, D., Saridin, F. N., Hilal, S., Villaraza, S., Gyanwali, B., Ihara, M., Vrooman, H., Weekes, A. A., Totman, J. J., Robins, E. G., Chen, C. P., & Reilhac, A. (2020). Improved quantification of amyloid burden and associated biomarker cut-off points: results from the first amyloid Singaporean cohort with overlapping cerebrovascular disease. European Journal of Nuclear Medicine and Molecular Imaging, 47(2), 319-331.
DOI: 10.1007/s00259-019-04642-8
Kan, C. N., Gyanwali, B., Hilal, S., Ng, K. P., Venketasubramanian, N., Chen, C. L. H., & Xu, X. (2020). Neuropsychiatric Correlates of Small Vessel Disease Progression in Incident Cognitive Decline: Independent and Interactive Effects. Journal of Alzheimer's Disease, 73(3), 1053-1062.
DOI: 10.3233/JAD-190999
Gyanwali, B., Hilal, S., Venketasubramanian, N., Chen, C., & Loo, J. H. Y. (2020). Hearing handicap in Asian patients with dementia. American Journal of Otolaryngology, 41(2), 102-377.
DOI: 10.1016/j.amjoto.2019.102377
Tan, C. H., Hilal, S., Xu, X., Vrooman, H., Cheng, C. Y., Wong, T. Y., Venketasubramanim, N., & Chen, C. (2020). MRI Markers of Mixed Pathology and Cognitive Impairment in Multiethnic Asians. Journal of Alzheimer's Disease, (Preprint), 1-9.
DOI: 10.3233/JAD-190866
Venketasubramanian, N., Moorakonda, R. B., Lu, Q., Chen, C. L., & CHIMES Investigators. (2020). Frequency and Clinical Impact of Serious Adverse Events on Post-Stroke Recovery with NeuroAiD (MLC601) versus Placebo: The CHInese Medicine Neuroaid Efficacy on Stroke Recovery Study. Cerebrovascular Diseases, 49(2), 192-199.
DOI: 10.1159/000506070
Wong, L. C. K., Wong, M. Y. Z., Tan, C. S., Vrooman, H., Venketasubramanian, N., Cheng, C. Y., Chen, C., & Hilal, S. (2020). Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study. Scientific Reports (Nature Publisher Group), 10(1).
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Hilal, S., Xin, X., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2017). Intracranial stenosis in cognitive impairment and dementia. Journal of Cerebral Blood Flow & Metabolism, 37(6), 2262-2269.
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Chen, C. L., Young, S. H., Gan, H. H., Singh, R., Lao, A. Y., Baroque, A. C., 2nd, Chang, H. M., Hiyadan, J. H., Chua, C. L., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P., de Silva, H. A., Towanabut, S., Suwanwela, N. C., Poungvarin, N., Chankrachang, S., Wong, K. S., Eow, G. B., Navarro, J. C., Venketasubramanian, N., Lee, C. F., Bousser, M. G., & Investigators, C. S. (2013). Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study. Stroke, 44(8), 2093-2100.
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Ikram, M. K., Ong, Y. T., Cheung, C. Y., & Wong, T. Y. (2013). Retinal vascular caliber measurements: clinical significance, current knowledge and future perspectives. Ophthalmologica, 229(3), 125-136.
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Dong, Y., Pang, W. S., Lim, L. B., Yang, Y. H., Morris, J. C., Hilal, S., Venketasubramanian, N., & Chen, C. L. (2013). The informant AD8 is superior to participant AD8 in detecting cognitive impairment in a memory clinic setting. J Alzheimers Dis, 35(1), 159-168.
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Ikram, M. K., Cheung, C. Y., Lorenzi, M., Klein, R., Jones, T. L., Wong, T. Y., & Group, N. J. W. o. R. B. f. D. (2013). Retinal vascular caliber as a biomarker for diabetes microvascular complications. Diabetes Care, 36(3), 750-759.
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Li, X., Wong, W. L., Cheung, C. Y., Cheng, C. Y., Ikram, M. K., Li, J., Chia, K. S., & Wong, T. Y. (2013). Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians. Invest Ophthalmol Vis Sci, 54(5), 3650-3656.
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Lim, M., Sasongko, M. B., Ikram, M. K., Lamoureux, E., Wang, J. J., Wong, T. Y., & Cheung, C. Y. (2013). Systemic associations of dynamic retinal vessel analysis: a review of current literature. Microcirculation, 20(3), 257-268.
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Lim, Y. A., Murray, L. A., Lai, M. K., & Chen, C. (2013). NeuroAiD(R) (MLC601) and amyloid precursor protein processing. Cerebrovasc Dis, 35 Suppl 1, 30-37.
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Nagaendran, K., Chen, L. H., Chong, M. S., Chua, E. V., Goh, C. K., Kua, J., Lee, T., Shiong, L. W., Marziyana, A. R., Ng, C. C., Ng, L. L., Seow, D., Sitoh, Y. Y., Yap, L. K., Yeo, D., & Yeo, Y. (2013). Ministry of health clinical practice guidelines: dementia. Singapore Med J, 54(5), 293-298; quiz 299.
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Navarro, J. C., Chen, C. L., Lagamayo, P. D., Geslani, M. B., Eow, G. B., Poungvarin, N., de Silva, A., Wong, L. K., Venketasubramanian, N., & Investigators, C. (2013). CHIMES-I: sub-group analyzes of the effects of NeuroAiD according to baseline brain imaging characteristics among patients randomized in the CHIMES study. Int J Stroke, 8(6), 491-494.
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Ong, S. Y., Ikram, M. K., Haaland, B. A., Cheng, C. Y., Saw, S. M., Wong, T. Y., & Cheung, C. Y. (2013). Myopia and cognitive dysfunction: the singapore malay eye study. Invest Ophthalmol Vis Sci, 54(1), 799-803.
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Thong, J. Y., Hilal, S., Wang, Y., Soon, H. W., Dong, Y., Collinson, S. L., Anh, T. T., Ikram, M. K., Wong, T. Y., Venketasubramanian, N., Chen, C., & Qiu, A. (2013). Association of silent lacunar infarct with brain atrophy and cognitive impairment. J Neurol Neurosurg Psychiatry, 84(11), 1219-1225.
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Catindig, J. A., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2012). Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors. J Neurol Sci, 321(1-2), 11-16.
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Cavalieri, M., Schmidt, R., Chen, C., Mok, V., de Freitas, G. R., Song, S., Yi, Q., Ropele, S., Grazer, A., Homayoon, N., Enzinger, C., Loh, K., Wong, K. S., Wong, A., Xiong, Y., Chang, H. M., Wong, M. C., Fazekas, F., Eikelboom, J. W., Hankey, G. J., & Group, V. T. S. (2012). B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy. Stroke, 43(12), 3266-3270.
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Cheung, C. Y., Ikram, M. K., Sabanayagam, C., & Wong, T. Y. (2012). Retinal microvasculature as a model to study the manifestations of hypertension. Hypertension, 60(5), 1094-1103.
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De Silva, D. A., Woon, F. P., Manzano, J. J., Liu, E. Y., Chang, H. M., Chen, C., Wang, J. J., Mitchell, P., Kingwell, B. A., Cameron, J. D., Lindley, R. I., Wong, T. Y., Wong, M. C., & behalf of the MultiCentre Retinal Stroke Study Collaborative, G. (2012). The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. J Hum Hypertens, 26(12), 716- 722.
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Dong, Y., Lee, W. Y., Basri, N. A., Collinson, S. L., Merchant, R. A., Venketasubramanian, N., & Chen, C. L. (2012). The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. Int Psychogeriatr, 24(11), 1749-1755.
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Dong, Y., Teoh, H. L., Chan, B. P., Ning, C., Yeo, T. T., Sinha, A. K., Venketasubramanian, N., Slavin, M. J., Sachdev, P., Collinson, S. L., Chen, C., & Sharma, V. K. (2012). Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study. J Neurol Sci, 322(1-2), 112-116.
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Dong, Y., Venketasubramanian, N., Chan, B. P., Sharma, V. K., Slavin, M. J., Collinson, S. L., Sachdev, P., Chan, Y. H., & Chen, C. L. (2012). Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke. J Neurol Neurosurg Psychiatry, 83(6), 580-585.
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Geeganage, C. M., Diener, H. C., Algra, A., Chen, C., Topol, E. J., Dengler, R., Markus, H. S., Bath, M. W., Bath, P. M., & Acute Antiplatelet Stroke Trialists, C. (2012). Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and metaanalysis of randomized controlled trials. Stroke, 43(4), 1058-1066.
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Ikram, M. K., Cheung, C. Y., Wong, T. Y., & Chen, C. P. (2012). Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry, 83(9), 917-922.
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Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., & Group, V. I. T. P. S. T. S. (2012). Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial. Stroke, 43(6), 1572-1577.
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Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., & group, V. t. s. (2012). Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol, 11(6), 512-520.
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Manzano, J. J., De Silva, D. A., Pascual, J. L., Chang, H. M., Wong, M. C., & Chen, C. P. (2012). Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. Atherosclerosis, 223(1), 219-222.
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Ong, S. Y., Cheung, C. Y., Li, X., Lamoureux, E. L., Ikram, M. K., Ding, J., Cheng, C. Y., Haaland, B. A., Saw, S. M., Venketasubramanian, N., Chen, C. P., & Wong, T. Y. (2012). Visual impairment, agerelated eye diseases, and cognitive function: the Singapore Malay Eye study. Arch Ophthalmol, 130(7), 895-900.
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Saini, M., Ikram, K., Hilal, S., Qiu, A., Venketasubramanian, N., & Chen, C. (2012). Silent stroke: not listened to rather than silent. Stroke, 43(11), 3102-3104.
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Sheng, Y., Lee, J. H., Medhurst, A. D., Wilcock, G. K., Esiri, M., Wong, P. T., Chen, C. P., & Lai, M. K. (2012). Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. J Neurol Sci, 315(1-2), 110-114.
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Wang, Q., Chen, C., Chen, X. Y., Han, J. H., Soo, Y., Leung, T. W., Mok, V., & Wong, K. S. (2012). Low-molecular-weight heparin and early neurologic deterioration in acute stroke caused by large artery occlusive disease. Arch Neurol, 69(11), 1454-1460.
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Wang, Q. S., Chen, C., Chen, X. Y., Han, J. H., Soo, Y., Leung, T. W., Mok, V., & Wong, K. S. (2012). Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study. Stroke, 43(2), 346-349.
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Wang, Y., Catindig, J. A., Hilal, S., Soon, H. W., Ting, E., Wong, T. Y., Venketasubramanian, N., Chen, C., & Qiu, A. (2012). Multi-stage segmentation of white matter hyperintensity, cortical and lacunar infarcts. Neuroimage, 60(4), 2379-2388.
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De Silva, D. A., Manzano, J. J., Liu, E. Y., Woon, F. P., Wong, W. X., Chang, H. M., Chen, C., Lindley, R. I., Wang, J. J., Mitchell, P., Wong, T. Y., Wong, M. C., & Multi-Centre Retinal Stroke Study, G. (2011). Retinal microvascular changes and subsequent vascular events after ischemic stroke. Neurology, 77(9), 896-903.
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Goh, C. W., Aw, C. C., Lee, J. H., Chen, C. P., & Browne, E. R. (2011). Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug Metab Dispos, 39(3), 402-411.
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Lai, M. K., Tsang, S. W., Esiri, M. M., Francis, P. T., Wong, P. T., & Chen, C. P. (2011). Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease. Psychopharmacology (Berl), 213(2-3), 431-439.
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Aisa, B., Gil-Bea, F. J., Solas, M., Garcia-Alloza, M., Chen, C. P., Lai, M. K., Francis, P. T., & Ramirez, M. J. (2010). Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. J Alzheimers Dis, 20(2), 659-668.
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Chen, C. L., Willis, B. A., Mooney, L., Ong, G. K., Lim, C. N., Lowe, S. L., Tauscher-Wisniewski, S., Cutler, G. B., Jr., & Wiss, S. D. (2010). Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation. Br J Clin Pharmacol, 70(6), 886- 894.
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Dong, Y., Sharma, V. K., Chan, B. P., Venketasubramanian, N., Teoh, H. L., Seet, R. C., Tanicala, S., Chan, Y. H., & Chen, C. (2010). The Montreal Cognitive Assessment (MoCA) is superior to the MiniMental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. J Neurol Sci, 299(1-2), 15-18.
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Group, V. T. S. (2010). B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebocontrolled trial. Lancet Neurol, 9(9), 855-865.
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Hankey, G. J., Wong, K. S., Chankrachang, S., Chen, C., Crimmins, D., Frayne, J., Kim, J. S., Li, Y., Liou, C. W., Merican, J. S., Misbach, J., Navarro, J., Shinohara, Y., Wang, Y., Yoon, B. W., Working Group on, S., & Lipids Management in Asia Consensus, P. (2010). Management of cholesterol to reduce the burden of stroke in Asia: consensus statement. Int J Stroke, 5(3), 209-216.
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Hao, Q., Chang, H. M., Wong, M. C., Wong, K. S., & Chen, C. (2010). Frequency of microemboli signal in stroke patients treated with low molecular weight heparin or aspirin. J Neuroimaging, 20(2), 118- 121.
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Lai, M. K., Chen, C. P., Hope, T., & Esiri, M. M. (2010). Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia. Neuroreport, 21(17), 1111-1115.
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Lee, J. H., Agacinski, G., Williams, J. H., Wilcock, G. K., Esiri, M. M., Francis, P. T., Wong, P. T., Chen, C. P., & Lai, M. K. (2010). Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. Neurochem Int, 57(8), 985-989.
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Narasimhalu, K., Effendy, S., Sim, C. H., Lee, J. M., Chen, I., Hia, S. B., Xue, H. L., Corrales, M. P., Chang, H. M., Wong, M. C., Chen, C. P., & Tan, E. K. (2010). A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease. Acta Neurol Scand, 121(4), 217-224.
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Seet, R. C., Kasiman, K., Gruber, J., Tang, S. Y., Wong, M. C., Chang, H. M., Chan, Y. H., Halliwell, B., & Chen, C. P. (2010). Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. Atherosclerosis, 209(1), 215-219.
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Tan, M. G., Chua, W. T., Esiri, M. M., Smith, A. D., Vinters, H. V., & Lai, M. K. (2010). Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. J Neurosci Res, 88(6), 1157-1169.
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Tsang, S. W., Keene, J., Hope, T., Spence, I., Francis, P. T., Wong, P. T., Chen, C. P., & Lai, M. K. (2010). A serotoninergic basis for hyperphagic eating changes in Alzheimer's disease. J Neurol Sci, 288(1-2), 151-155.
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Venketasubramanian, N., Sahadevan, S., Kua, E. H., Chen, C. P., & Ng, T. P. (2010). Interethnic differences in dementia epidemiology: global and Asia-Pacific perspectives. Dement Geriatr Cogn Disord, 30(6), 492-498.
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Wong, K. S., Chen, C., Fu, J., Chang, H. M., Suwanwela, N. C., Huang, Y. N., Han, Z., Tan, K. S., Ratanakorn, D., Chollate, P., Zhao, Y., Koh, A., Hao, Q., Markus, H. S., & investigators, C. s. (2010). Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blindedendpoint trial. Lancet Neurol, 9(5), 489-497.
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Young, S. H., Zhao, Y., Koh, A., Singh, R., Chan, B. P., Chang, H. M., Venketasubramanian, N., Chen, C., & Investigators, C. (2010). Safety profile of MLC601 (Neuroaid) in acute ischemic stroke patients: A Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study. Cerebrovasc Dis, 30(1), 1-6.
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Year 2009
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Chen, C., Venketasubramanian, N., Gan, R. N., Lambert, C., Picard, D., Chan, B. P., Chan, E., Bousser, M. G., & Xuemin, S. (2009). Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery. Stroke, 40(3), 859-863.
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De Silva, D. A., Ancalan, M., Doshi, K., Chang, H. M., Wong, M. C., & Chen, C. (2009). Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. Eur J Neurol, 16(5), 643-645.
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De Silva, D. A., Liew, G., Wong, M. C., Chang, H. M., Chen, C., Wang, J. J., Baker, M. L., Hand, P. J., Rochtchina, E., Liu, E. Y., Mitchell, P., Lindley, R. I., & Wong, T. Y. (2009). Retinal vascular caliber and extracranial carotid disease in patients with acute ischemic stroke: the Multi-Centre Retinal Stroke (MCRS) study. Stroke, 40(12), 3695-3699.
DOI: 10.1161/STROKEAHA.109.559435
De Silva, D. A., Woon, F. P., Chen, C., Chang, H. M., & Wong, M. C. (2009). Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity? J Neurol Sci, 276(1-2), 126-129.
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De Silva, D. A., Woon, F. P., Chen, C. L., Chang, H. M., & Wong, M. C. (2009). Ethnic South Asian ischaemic stroke patients have a higher prevalence of a family history of vascular disease compared to age, gender and diabetes-matched ethnic Chinese subjects. J Neurol Sci, 285(1-2), 118-120.
DOI: 10.1016/j.jns.2009.06.013
De Silva, D. A., Woon, F. P., Gan, H. Y., Chen, C. P., Chang, H. M., Koh, T. H., Kingwell, B. A., Cameron, J. D., & Wong, M. C. (2009). Arterial stiffness is associated with intracranial large artery disease among ethnic Chinese and South Asian ischemic stroke patients. J Hypertens, 27(7), 1453- 1458.
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De Silva, D. A., Woon, F. P., Lee, M. P., Chen, C. L., Chang, H. M., & Wong, M. C. (2009). Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke. J Stroke Cerebrovasc Dis, 18(6), 424-427.
DOI: 10.1016/j.jstrokecerebrovasdis.2009.01.010
Gruber, J., Tang, S. Y., Jenner, A. M., Mudway, I., Blomberg, A., Behndig, A., Kasiman, K., Lee, C. Y., Seet, R. C., Zhang, W., Chen, C., Kelly, F. J., & Halliwell, B. (2009). Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. Antioxid Redox Signal, 11(8), 1767-1776.
DOI: 10.1089/ARS.2008.2364
Kandiah, N., Narasimhalu, K., Lee, J., & Chen, C. L. (2009). Differences exist in the cognitive profile of mild Alzheimer's disease and subcortical ischemic vascular dementia. Dement Geriatr Cogn Disord, 27(5), 399-403.
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Kasiman, K., Eikelboom, J. W., Hankey, G. J., Lee, S. P., Lim, J. P., Lee, J. H., Chang, H. M., Wong, M. C., & Chen, C. P. (2009). Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in Singaporean stroke patients. Stroke, 40(6), 2209-2211.
DOI: 10.1161/STROKEAHA.108.535237
Kidwell, C. S., Lees, K. R., Muir, K. W., Chen, C., Davis, S. M., De Silva, D. A., Weir, C. J., Starkman, S., Alger, J. R., Saver, J. L., & Investigators, M. I. (2009). Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial. Stroke, 40(5), 1704-1709.
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Kong, K. H., Wee, S. K., Ng, C. Y., Chua, K., Chan, K. F., Venketasubramanian, N., & Chen, C. (2009). A double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional chinese medicine Neuroaid (MLC 601) in enhancing recovery after stroke (TIERS). Cerebrovasc Dis, 28(5), 514-521.
DOI: 10.1159/000247001
Lindley, R. I., Wang, J. J., Wong, M. C., Mitchell, P., Liew, G., Hand, P., Wardlaw, J., De Silva, D. A., Baker, M., Rochtchina, E., Chen, C., Hankey, G. J., Chang, H. M., Fung, V. S., Gomes, L., Wong, T. Y., Multi-Centre, R., & Stroke Study Collaborative, G. (2009). Retinal microvasculature in acute lacunar stroke: a cross-sectional study. Lancet Neurol, 8(7), 628-634.
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Medhurst, A. D., Roberts, J. C., Lee, J., Chen, C. P., Brown, S. H., Roman, S., & Lai, M. K. (2009). Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice. Br J Pharmacol, 157(1), 130-138.
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Narasimhalu, K., Ang, S., De Silva, D. A., Wong, M. C., Chang, H. M., Chia, K. S., Auchus, A. P., & Chen, C. (2009). Severity of CIND and MCI predict incidence of dementia in an ischemic stroke cohort. Neurology, 73(22), 1866-1872.
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Qiu, A., Fennema-Notestine, C., Dale, A. M., Miller, M. I., & Alzheimer's Disease Neuroimaging, I. (2009). Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroimage, 45(3), 656-661.
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Qiu, A., Taylor, W. D., Zhao, Z., MacFall, J. R., Miller, M. I., Key, C. R., Payne, M. E., Steffens, D. C., & Krishnan, K. R. (2009). APOE related hippocampal shape alteration in geriatric depression. Neuroimage, 44(3), 620-626.
DOI: 10.1016/j.neuroimage.2008.10.010
Sare, G. M., Gray, L. J., Wardlaw, J., Chen, C., Bath, P. M., & Investigators, E. T. (2009). Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial. Blood Press Monit, 14(1), 20-25.
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Tan, E. K., Lee, J., Chen, C. P., Teo, Y. Y., Zhao, Y., & Lee, W. L. (2009). SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese. Neurobiol Aging, 30(7), 1048-1051.
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Seet, R. C., & Chen, C. P. (2009). Optimizing antiplatelet therapy in high-risk patients with atrial fibrillation: insights from Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE A). Stroke, 40(12), 3883-3885.
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Tan, E. K., Lee, J., Chen, C. P., Wong, M. C., & Zhao, Y. (2009). Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiol Aging, 30(3), 501-502.
DOI: 10.1016/j.neurobiolaging.2007.07.010
Venketasubramanian, N., Chen, C. L., Gan, R. N., Chan, B. P., Chang, H. M., Tan, S. B., Picard, D., Navarro, J. C., Baroque, A. C., 2nd, Poungvarin, N., Donnan, G. A., Bousser, M. G., & Investigators, C. (2009). A double-blind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study). Int J Stroke, 4(1), 54-60.
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Year 2008
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Baker, M. L., Hand, P. J., Wang, J. J., & Wong, T. Y. (2008). Retinal signs and stroke: revisiting the link between the eye and brain. Stroke, 39(4), 1371-1379.
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De Silva, D., Woon, F. P., Chen, C., Chang, H. M., Kingwell, B., Cameron, J., & Wong, M. C. (2008). Profile and associations of central pulse wave velocity and central pulse pressure among ischemic stroke patients. Eur J Neurol, 15(2), 196-198.
DOI: 10.1111/j.1468-1331.2007.02024.x
De Silva, D. A., Lee, M. P., Wong, M. C., Chang, H. M., & Chen, C. L. (2008). Limb-shaking transient ischemic attack with distal micro-embolic signals and impaired cerebrovascular reactivity using transcranial Doppler. Ann Acad Med Singapore, 37(7), 619-620.
DOI: 10.1016/S1873-9598(10)70022-3
De Silva, D. A., Wong, T. Y., Chang, H. M., Ng, B. F., Tikellis, G., Saw, S. M., Woon, F. P., Chen, C. P., & Wong, M. C. (2008). Is routine retinal examination useful in patients with acute ischemic stroke? Stroke, 39(4), 1352-1354.
DOI: 10.1161/STROKEAHA.107.495648
De Silva, D. A., Woon, F. P., Gan, H. Y., Cameron, J., Kingwell, B., Koh, T. H., Chen, C., Chang, H. M., & Wong, M. C. (2008). Arterial stiffness, metabolic syndrome and inflammation amongst Asian ischaemic stroke patients. Eur J Neurol, 15(8), 872-875.
DOI: 10.1111/j.1468-1331.2008.02208.x
De Silva, D. A., Woon, F. P., Gan, H. Y., Chen, C., Chang, H. M., Cameron, J., Kingwell, B., & Wong, M. C. (2008). Arterial stiffness is associated with raised levels of the inflammatory marker erythrocyte sedimentation rate among ischaemic stroke patients. Intern Med J, 38(12), 918-920.
DOI: 10.1111/j.1445-5994.2008.01811.x
De Silva, D. A., Woon, F. P., Moe, K. T., Chen, C. L., Chang, H. M., & Wong, M. C. (2008). Concomitant coronary artery disease among Asian ischaemic stroke patients. Ann Acad Med Singapore, 37(7), 573- 575.
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Gan, R., Lambert, C., Lianting, J., Chan, E. S., Venketasubramanian, N., Chen, C., Chan, B. P., Samama, M. M., & Bousser, M. G. (2008). Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients. Cerebrovasc Dis, 25(5), 450- 456.
DOI: 10.1159/000126919
Lai, M. K., Tan, M. G., Kirvell, S., Hobbs, C., Lee, J., Esiri, M. M., Chen, C. P., & Francis, P. T. (2008). Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology. J Neural Transm (Vienna), 115(8), 1165-1172.
DOI: 10.1007/s00702-008-0067-y
Venketasubramanian, N., & Chen, C. L. (2008). Burden of stroke in Singapore. Int J Stroke, 3(1), 51- 54.
DOI: 10.1111/j.1747-4949.2008.00181.x
Marcos, B., Garcia-Alloza, M., Gil-Bea, F. J., Chuang, T. T., Francis, P. T., Chen, C. P., Tsang, S. W., Lai, M. K., & Ramirez, M. J. (2008). Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimers Dis, 14(1), 43-50.
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Narasimhalu, K., Lee, J., Auchus, A. P., & Chen, C. P. (2008). Improving detection of dementia in Asian patients with low education: combining the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly. Dement Geriatr Cogn Disord, 25(1), 17-22.
DOI: 10.1159/000111128
Sahadevan, S., Saw, S. M., Gao, W., Tan, L. C., Chin, J. J., Hong, C. Y., & Venketasubramanian, N. (2008). Ethnic differences in Singapore's dementia prevalence: the stroke, Parkinson's disease, epilepsy, and dementia in Singapore study. J Am Geriatr Soc, 56(11), 2061-2068.
DOI: 10.1111/j.1532-5415.2008.01992.x
Tsang, S. W., Francis, P. T., Esiri, M. M., Wong, P. T., Chen, C. P., & Lai, M. K. (2008). Loss of [3H]4- DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis. Psychopharmacology (Berl), 198(2), 251-259.
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Tsang, S. W., Vinters, H. V., Cummings, J. L., Wong, P. T., Chen, C. P., & Lai, M. K. (2008). Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease. Neurobiol Aging, 29(10), 1524-1532.
DOI: 10.1016/j.neurobiolaging.2007.03.014