Loading...
MACC
Publications

Year 2022 -

  1. Xu, X., Chew, K. A., Wong, Z. X., Phua, A. K. S., Chong, E. J. Y., Teo, C. K. L., ... & Chen, C. L. H. (2022). The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol. The Journal of Prevention of Alzheimer's Disease, 1-9.
    DOI: 10.14283/jpad.2022.5
  2. Egle, M., Hilal, S., Tuladhar, A. M., Pirpamer, L., Hofer, E., Duering, M., ... & Markus, H. S. (2022). Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration. Journal of Neurology, Neurosurgery & Psychiatry, 93(1), 14-23.
    DOI: 10.1136/jnnp-2021-326571
  3. Tanaka, T., Gyanwali, B., Villaraza, S. G., Saridin, F. N., Vrooman, H., Ihara, M., ... & Hilal, S. (2022). The Association Between Standard Electrocardiography and Cerebral Small Vessel Disease in a Memory Clinic Study. Journal of Alzheimer's Disease, (Preprint), 1-13.
    DOI: 10.3233/JAD-215413
  4. Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H. J., Lim, J. S., Godefroy, O., ... & Stroke and Cognition (STROKOG) Collaboration. (2022). Long-Term Cognitive Decline After Stroke: An Individual Participant Data Meta-Analysis. Stroke.
    DOI: 10.1161/STROKEAHA.121.035796
  5. Tan, H. K., Narasimhalu, K., Ting, S. K. S., Hameed, S., Chang, H. M., De Silva, D. A., ... & Tan, E. K. (2022). B-vitamin supplementation on mitigating post-stroke cognition and neuropsychiatric sequelae: A randomized controlled trial. International Journal of Stroke.
    DOI: 10.1177/17474930221085880
  6. Hampel, H., Vergallo, A., Iwatsubo, T., Cho, M., Kurokawa, K., Wang, H., ... & Chen, C. (2022). Evaluation of major national dementia policies and health‐care system preparedness for early medical action and implementation. Alzheimer's & Dementia.
    DOI: 10.1002/alz.12655
  7. Chen, C. L., Lu, Q., Moorakonda, R. B., Kandiah, N., Tan, B. Y., Villaraza, S. G., ... & Venketasubramanian, N. (2022). Alzheimer's Disease THErapy With NEuroaid (ATHENE): A Randomized Double-Blind Delayed-Start Trial. Journal of the American Medical Directors Association, 23(3), 379-386.
    DOI: 10.1016/j.jamda.2021.10.018
  8. Beaman, C., Kozii, K., Hilal, S., Liu, M., Spagnolo-Allende, A. J., Polanco-Serra, G., ... & Gutierrez, J. (2022). Cerebral Microbleeds, Cerebral Amyloid Angiopathy, and Their Relationships to Quantitative Markers of Neurodegeneration. Neurology.
    DOI: 10.1212/WNL.0000000000200142
  9. Ferro, D. A., Kuijf, H. J., Hilal, S., van Veluw, S. J., van Veldhuizen, D., Venketasubramanian, N., ... & Chen, C. (2022). Association Between Cerebral Cortical Microinfarcts and Perilesional Cortical Atrophy on 3T MRI. Neurology, 98 (6).
    DOI: 10.1212/WNL.0000000000013140
  10. Rajeev, V., Fann, D. Y., Dinh, Q. N., Kim, H. A., De Silva, T. M., Lai, M. K., ... & Arumugam, T. V. (2022). Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment. Theranostics, 12(4), 1639.
    DOI: 10.7150/thno.68304
  11. Poh, L., Sim, W. L., Jo, D. G., Dinh, Q. N., Drummond, G. R., Sobey, C. G., ... & Arumugam, T. V. (2022). The role of inflammasomes in vascular cognitive impairment. Molecular neurodegeneration, 17(1), 1-28.
    DOI: 10.1186/s13024-021-00506-8
  12. Anderson, C. S., Rodgers, A., De Silva, H. A., Martins, S. O., Klijn, C. J., Senanayake, B., ... & Chalmers, J. (2022). Triple Therapy Prevention of Recurrent Intracerebral Disease Events Trial: Rationale, design and progress. International Journal of Stroke.
    DOI: 10.1177/17474930211068671
  13. Hampel, H., Shaw, L. M., Aisen, P., Chen, C., Lleó, A., Iwatsubo, T., ... & Vergallo, A. (2022). State‐of‐the‐art of lumbar puncture and its place in the journey of patients with Alzheimer's disease. Alzheimer's & Dementia, 18(1), 159-177.
    DOI: 10.1002/alz.12372
  14. Kan, C. N., Xu, X., Schmetterer, L., Venketasubramanian, N., Chen, C., & Tan, C. H. (2022). Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition. Neurobiology of aging, 109, 239-246.
    DOI: 10.1016/j.neurobiolaging.2021.10.008
  15. Saridin, F. N., Chew, K. A., Reilhac, A., Gyanwali, B., Villaraza, S. G., Tanaka, T., ... & Hilal, S. (2022). Cerebrovascular disease in suspected non‐Alzheimer's pathophysiology and cognitive decline over time. European Journal of Neurology.
    DOI: 10.1111/ene.15337
  16. Tan, C. H., Chew, J., Zhang, L., Gulyás, B., Chen, C., & Alzheimer's Disease Neuroimaging Initiative. (2022). Differential effects of white matter hyperintensities and regional amyloid deposition on regional cortical thickness. Neurobiology of Aging, 115, 12-19.
    DOI: 10.1016/j.neurobiolaging.2022.03.013

Year 2021 -

  1. Zhang, L., Biessels, G. J., Hilal, S., Chong, J. S. X., Liu, S., Shim, H. Y., Xu X., Chong E. J. Y., Wong Z. X., Loke Y. M., Venketasubramaniam N., Tan B. Y., Chen C. L. H., & Zhou, J. H. (2021). Cerebral microinfarcts affect brain structural network topology in cognitively impaired patients. Journal of Cerebral Blood Flow & Metabolism, 41(1), 105-115.
    DOI: 10.1177/0271678X20902187
  2. Kandiah, N., Chan, Y. F., Chen, C., Dasig, D., Dominguez, J., Han, S. H., Jia J., Kim S., Limpawattana P., Ng L. L., Nguyen D. T., Ong P. A., Raya-Ampil E., Saedon N., Senanarong V., Setiati S., Singh H., Suthisisang C., Trang T. M., Turana Y., Venketasubramanian N., Yong F. M., Youn Y. C., & Ihl, R. (2020). Strategies for the use of Ginkgo biloba extract, EGb 761®, in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neuroscience & Therapeutics.
    DOI: 10.1111/cns.13536
  3. Lam, B. W. S., Yam, T. Y. A., Chen, C. P., Lai, M. K., Ong, W. Y., & Herr, D. R. (2021). The noncanonical chronicles: Emerging roles of sphingolipid structural variants. Cellular Signalling, 79, 109-890.
    DOI: 10.1016/j.cellsig.2020.109890
  4. Liu, H., Nai, Y. H., Saridin, F., Tanaka, T., O’Doherty, J., Hilal, S., Gyanwali, B., Chen, C. P., Robins, E. G., & Reilhac, A. Improved amyloid burden quantification with nonspecific estimates using deep learning. European Journal of Nuclear Medicine and Molecular Imaging, 1-12
    DOI: 10.1007/s00259-020-05131-z
  5. Hilal, S., Mutsaerts, H. J., Ferro, D. A., Petr, J., Kuijf, H. J., Biessels, G. J., & Chen, C. The Effects of Intracranial Stenosis on Cerebral Perfusion and Cognitive Performance. Journal of Alzheimer's Disease, (Preprint), 1-12.
    DOI: 10.3233/JAD-201131
  6. Fenwick, E. K., Gan, A. T., Man, R. E., Gupta, P., Sabanayagam, C., Cheng, C. Y., Chen, C. L., Cheung, C. Y., Wong, K. H., Venketasubramanian, N., Xu, X., Hilal, S., Chong, E. J. Y., Tham, Y. C., Wong, T. Y., & Lamoureux, E. L. (2021). Vision, vision-specific functioning and mobility, and their relationship with clinically assessed cognitive impairment. Age and Ageing.
    DOI: 10.1016/j.amjoto.2019.102377
  7. Best, J. G., Ambler, G., Wilson, D., Lee, K. J., Lim, J. S., Shiozawa, M., ... & Marsh, R. (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. The Lancet Neurology, 20(4), 294-303.
    DOI: 10.1016/S1474-4422(21)00024-7
  8. Chai, Y. L., Chong, J. R., Raquib, A. R., Xu, X., Hilal, S., Venketasubramanian, N., ... & Lai, M. K. (2021). Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment. Scientific reports, 11(1), 1-11.
    DOI: 10.1038/s41598-021-83601-6
  9. Tanaka, T., Ruifen, J. C., Nai, Y. H., Tan, C. H., Lim, C. Z., Zhang, Y., ... & Chen, C. (2021). Head‐to‐head comparison of amplified plasmonic exosome Aβ42 platform and single‐molecule array immunoassay in a memory clinic cohort. European journal of neurology, 28(5), 1479-1489.
    DOI: 10.1111/ene.14704
  10. Xu, X., Ni Kan, C., Li-Hsian Chen, C., & Hilal, S. (2021). Long-term neurobehavioral correlates of brain cortical microinfarcts in a memory clinic cohort in Singapore. International Journal of Stroke, 17474930211006294.
    DOI: 10.1177/17474930211006294
  11. Lim, M. J. R., Tan, C. S., Gyanwali, B., Chen, C., & Hilal, S. (2021). The effect of intracranial stenosis on cognitive decline in a memory clinic cohort. European Journal of Neurology.
    DOI: 10.1111/ene.14788
  12. Shim, Y. S., Park, K. H., Chen, C., Dominguez, J. C., Kang, K., Kim, H. J., ... & Kim, S. (2021). Caregiving, care burden and awareness of caregivers and patients with dementia in Asian locations: a secondary analysis. BMC geriatrics, 21(1), 1-10.
    DOI: 10.1186/s12877-021-02178-x
  13. Chua, X.Y., Ho, L.T.Y., Xiang, P. et al. Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromol Med 23, 47–67 (2021).
    DOI: 10.1007/s12017-020-08632-0
  14. Hilal, S., Liu, S., Wong, T. Y., Vrooman, H., Cheng, C. Y., Venketasubramanian, N., ... & Zhou, J. H. (2021). White matter network damage mediates association between cerebrovascular disease and cognition. Journal of Cerebral Blood Flow & Metabolism, 0271678X21990980.
    DOI: 10.1177/0271678X21990980
  15. Chew, K. A., Xu, X., Siongco, P., Villaraza, S., Phua, A. K. S., Wong, Z. X., ... & Chen, C. (2021). SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)–pilot: A feasibility study. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), e12141.
    DOI: 10.1002/trc2.12141
  16. Chong, J. R., Ashton, N. J., Karikari, T. K., Tanaka, T., Saridin, F. N., Reilhac, A., ... & Chen, C. P. (2021). Plasma P‐tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease. Alzheimer's & Dementia.
    DOI: 10.1002/alz.12332
  17. Chen, C. L., Nguyen, T. H., Marasigan, S., Lee, C. F., Lu, Q., Kandiah, N., ... & Venketasubramanian, N. (2021). NEURoaid II (MLC901) in cognitively Impaired not demenTEd patientS (NEURITES): A pilot double blind, placebo‐controlled randomized trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), e12161.
    DOI: 10.1002/trc2.12161
  18. Weaver, N. A., Kuijf, H. J., Aben, H. P., Abrigo, J., Bae, H. J., Barbay, M., ... & Biessels, G. J. (2021). Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. The Lancet Neurology, 20(6), 448-459.
    DOI: 10.1016/S1474-4422(21)00060-0
  19. Gyanwali, B., Lai, M. K., Lui, B., Liew, O. W., Venketasubramanian, N., Richards, A. M., ... & Hilal, S. (2021). Blood-Based Cardiac Biomarkers and the Risk of Cognitive Decline, Cerebrovascular Disease, and Clinical Events. Stroke, STROKEAHA-120.
    DOI: 10.1161/STROKEAHA.120.032571
  20. Gyanwali, B., Xue Ting Cai, C., Chen, C., Vrooman, H., Tan, C. S., & Hilal, S. The Effects of Mean of Visit-to-Visit Blood Pressure on Incident Brain Vascular Lesions and Functional-Cognitive Decline. Journal of Alzheimer's Disease, (Preprint), 1-12.
    DOI: 10.3233/JAD-210188
  21. Hilal, S., Biesbroek, J. M., Vrooman, H., Chong, E., Kuijf, H. J., Venketasubramanian, N., ... & Chen, C. (2021). The impact of strategic white matter hyperintensity lesion location on language. The American Journal of Geriatric Psychiatry, 29(2), 156-165.
    DOI: 10.1016/j.jagp.2020.06.009
  22. Wu, L. Y., Cheah, I. K., Chong, J. R., Chai, Y. L., Tan, J. Y., Hilal, S., ... & Lai, M. K. (2021). Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia. Free Radical Biology and Medicine, 177, 201-211.
    DOI: 10.1016/j.freeradbiomed.2021.10.019
  23. Poh, L., Razak, S. M. B. A., Lim, H. M., Lai, M. K., Chen, C. L. H., Lim, L. H., ... & Fann, D. Y. (2021). AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusion. Experimental Neurology, 346, 113856.
    DOI: 10.1016/j.expneurol.2021.113856
  24. de Brito Robalo, B. M., Biessels, G. J., Chen, C., Dewenter, A., Duering, M., Hilal, S., ... & de Luca, A. (2021). Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease. NeuroImage: Clinical, 32, 102886.
    DOI: 10.1016/j.nicl.2021.102886
  25. Chen, C. L., & Rundek, T. (2021). Vascular Brain Health. Stroke, 52(11), 3700-3705.
    DOI: 10.1161/STROKEAHA.121.033450
  26. Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., ... & Vergallo, A. (2021). The amyloid-β pathway in alzheimer’s disease. Molecular psychiatry, 1-23.
    DOI: 10.1038/s41380-021-01249-0
  27. Zhao, X., Chong, E. J. Y., Qi, W., Pang, T., Xu, X., & Chen, C. (2021). Domain-Specific Cognitive Trajectories Among Patients with Minor Stroke or Transient Ischemic Attack in a 6-Year Prospective Asian Cohort: Serial Patterns and Indicators. Journal of Alzheimer's Disease, 83(2), 557-568.
    10.3233/JAD-210619
  28. Chong, J. R., Ashton, N. J., Karikari, T. K., Tanaka, T., Schöll, M., Zetterberg, H., ... & Lai, M. K. (2021). Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer’s disease: a focused review on recent advances. Journal of Neurology, Neurosurgery & Psychiatry, 92(11), 1231-1241.
    DOI: 10.1136/jnnp-2021-327370
  29. Rojer, A. G., Ramsey, K. A., Gomes, E. S. A., D’Andrea, L., Chen, C., Szoeke, C., ... & Maier, A. B. (2021). Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review. Mechanisms of ageing and development, 198, 111524.
    DOI: 10.1016/j.mad.2021.111524
  30. Poh, L., Rajeev, V., Selvaraji, S., Lai, M. K., Chen, C. L. H., Arumugam, T. V., & Fann, D. Y. (2021). Intermittent fasting attenuates inflammasome-associated apoptotic and pyroptotic death in the brain following chronic hypoperfusion. Neurochemistry International, 148, 105109.
    DOI: 10.1016/j.neuint.2021.105109
  31. Yuen, V., Ran, A., Shi, J., Sham, K., Yang, D., Chan, V. T., ... & Cheung, C. Y. (2021). Deep-Learning–Based Pre-Diagnosis Assessment Module for Retinal Photographs: A Multicenter Study. Translational vision science & technology, 10(11), 16-16.
    DOi: 10.1167/tvst.10.11.16
  32. Gyanwali, B., Lui, B., Tan, C. S., Chong, E. J., Vrooman, H., Chen, C., & Hilal, S. (2021). Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study. Current Alzheimer Research, 18(5), 399-413.
    DOI: 10.2174/1567205018666210820125543
  33. Truong, A. T., Tan, L. W., Chew, K. A., Villaraza, S., Siongco, P., Blasiak, A., ... & Ho, D. (2021). Harnessing CURATE. AI for N‐of‐1 Optimization Analysis of Combination Therapy in Hypertension Patients: A Retrospective Case Series. Advanced Therapeutics, 4(10), 2100091.
    DOI: 10.1002/adtp.202100091
  34. Vu, T. A., Fenwick, E. K., Gan, A. T., Man, R. E., Tan, B. K., Gupta, P., ... & Lamoureux, E. L. (2021). The bidirectional relationship between vision and cognition: a systematic review and meta-analysis. Ophthalmology, 128(7), 981-992.
    DOI: 10.1016/j.ophtha.2020.12.010
  35. Park, K. H., Yang, Y., Chen, C., Shim, Y. S., Domingueze, J. C., Lee, C. N., ... & Kim, S. (2021). Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia. Journal of clinical neurology (Seoul, Korea), 17(3), 376.
    DOi: 10.3988/jcn.2021.17.3.376
  36. Baik, S. H., Selvaraji, S., Fann, D. Y., Poh, L., Jo, D. G., Herr, D. R., ... & Arumugam, T. V. (2021). Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging. Aging (Albany NY), 13(11), 14651.
    DOI: 10.18632/aging.203123
  37. Cheung, C. Y., Mok, V., Foster, P. J., Trucco, E., Chen, C., & Wong, T. Y. (2021). Retinal imaging in Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 92(9), 983-994.
    DOI: 10.1136/jnnp-2020-325347
  38. Lam, B. Y. K., Yiu, B., Ampil, E., Chen, C. L. H., Dikot, Y., Dominguez, J. C., ... & Mok, V. C. T. (2021). High burden of cerebral white matter lesion in 9 Asian cities. Scientific reports, 11(1), 1-12.
    DOI: 10.1038/s41598-021-90746-x

Year 2020 -

  1. Chen, Y., & Chen, C. (2020). How to support the quality of life of people living with cognitive disorders: a (k) new challenge in the post‐COVID‐19 world. European Journal of Neurology, 27(9), 1742-1743.
    DOI: 10.1111/ene.143730
  2. Akiba, C., Gyanwali, B., Villaraza, S., Nakajima, M., Miyajima, M., Cheng, C. Y., Wong, T. Y., Venketasubramanian, N., Hilal, S., & Chen, C. (2020). The prevalence and clinical associations of Disproportionately Enlarged Subarachnoid Space Hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts. Journal of the Neurological Sciences, 408, 116-510.
    DOI: 10.1016/j.jns.2019.116510
  3. Ferro, D. A., Mutsaerts, H. J., Hilal, S., Kuijf, H. J., Petersen, E. T., Petr, J., van Veluw, S. J., Venketasubramanian, N., Boon Yeow, T., Jan Biessels, G., & Chen, C. (2020). Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion. Journal of Cerebral Blood Flow & Metabolism, 40(9), 1869-1878.
    DOI: 10.1177/0271678X19877403
  4. Yassi, N., Hilal, S., Xia, Y., Lim, Y. Y., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P. M., & Masters, C. L. (2020). Influence of comorbidity of cerebrovascular disease and amyloid-β on Alzheimer’s disease. Journal of Alzheimer's Disease, 73(3), 897-907.
    DOI: 10.3233/JAD-191028
  5. Kivipelto, M., Mangialasche, F., Snyder, H. M., Allegri, R., Andrieu, S., Arai, H., Baker, L., Belleville, S., Brodaty, H., Brucki, S. M., Calandri, I., Caramelli, P., Chen, C., Chertkow, H., Chew, E., Choi, S. H., Chowdhary, N., Crivelli, L., Torre, R., Du, Y., Dua, T., Espeland, M., Feldman, H. H., Hartmanis, M., Hartmann, T., Heffernan, M., Henry, C. J., Hong, C. H., Håkansson, K., Iwatsubo, T., Jeong, J. H., Jimenez-Maggiora, G., Koo, E. H., Launer, L. J., Lehtisalo, J., Lopera, F., Martínez-Lage, P., Martins, R., Middleton, L., Molinuevo, J. L., Montero-Odasso, M., Moon, S. Y., Morales-Pérez, K., Nitrini, R., Nygaard, H. B., Park, Y. K., Peltonen, M., Qiu, C., Quiroz, Y. T., Raman, R., Rao, N., Ravindranath, V., Rosenberg, A., Sakurai, T., Salinas, R. M., Scheltens, P., Sevlever, G., Soininen, H., Sosa, A. L., Suemoto, C. K., Tainta-Cuezva, M., Velilla, L., Wang, Y., Whitmer, R., Xu, X., Bain, L. J., Solomon, A., Ngandu, T., & Carrillo, M. C. (2020). World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimer's & Dementia, 16(7), 1078-1094.
    DOI: 10.1002/alz.12123
  6. Hilal, S., Tan, C. S., van Veluw, S. J., Xu, X., Vrooman, H., Tan, B. Y., Venketasubramanian, N., Biessels, G. J., & Chen, C. (2020). Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients. Journal of Cerebral Blood Flow & Metabolism, 40(1), 44-53.
    DOI: 10.1177/0271678X19835565
  7. Zhang, L., Zuo, X. N., Ng, K. K., Chong, J. S. X., Shim, H. Y., Ong, M. Q. W., Loke, Y. M., Choo, B. L., Chong, E. J. Y., Wong, Z. X., Hilal, S., Venketasubramanian, N., Tan, B. Y., Chen, C. L., & Zhou, J. H. (2020). Distinct BOLD variability changes in the default mode and salience networks in Alzheimer’s disease spectrum and associations with cognitive decline. Scientific Reports, 10(1), 1-12.
    DOI: 10.1038/s41598-020-63540-4
  8. Lim, Z. W., Chee, M. L., Da Soh, Z., Cheung, N., Dai, W., Sahil, T. Tao, Y., Majithia, S., Sabanayagam, C., Chen, C. L., Wong, T. Y., Cheng, C. Y., & Tham, Y. C. (2020). Association between visual impairment and decline in cognitive function in a multiethnic Asian population. JAMA Network Open, 3(4), e203560-e203560.
    DOI: 10.1001/jamanetworkopen.2020.3560
  9. Ng, S. S., Park, J. E., Meng, W., Chen, C. P., Kalaria, R. N., McCarthy, N. E., & Sze, S. K. (2020). Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation. ACS Omega, 5(23), 13528-13540.
    DOI: 10.1021/acsomega.9b04439
  10. Chew, K. A., Chong, E. J., Chen, C. L. & Xu, X. (2020). Psychometric Properties of the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network Neuropsychological Battery in an Asian Older Adult Sample. Journal of the American Medical Directors Association, 21(6), 879-883.
    DOI: 10.1016/j.jamda.2020.03.022
  11. Chua, X. Y., Chai, Y. L., Chew, W. S., Chong, J. R., Ang, H. L., Xiang, P., Camara, K., Howell, A. R., Torta, F., Wenk, M. R., Hilal, S., Venketasubramanian, N., Chen, C. P., Herr, D. R., & Lai, M. K. P. (2020). Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment. Alzheimer's Research & Therapy, 12(1), 1-12.
    DOI: 10.1186/s13195-020-00694-3
  12. Zhang, L., Mak, E., Reilhac, A., Shim, H. Y., Ng, K. K., Ong, M. Q. W., Ji, F., Chong, E., Xu, X., Wong, Z. X., Stephenson, M. C., Venketasubramaniam, N., Tan, B. Y., O’Brien, J., Zhou, H. J., Chen, C., & Alzheimer's Disease Neuroimaging Initiative. (2020). Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in non-demented elderly. Human Brain Mapping, 41(8), 2037-2047.
    DOI: 10.1002/hbm.24928
  13. Tanaka, T., Stephenson, M. C., Nai, Y. H., Khor, D., Saridin, F. N., Hilal, S., Villaraza, S., Gyanwali, B., Ihara, M., Vrooman, H., Weekes, A. A., Totman, J. J., Robins, E. G., Chen, C. P., & Reilhac, A. (2020). Improved quantification of amyloid burden and associated biomarker cut-off points: results from the first amyloid Singaporean cohort with overlapping cerebrovascular disease. European Journal of Nuclear Medicine and Molecular Imaging, 47(2), 319-331.
    DOI: 10.1007/s00259-019-04642-8
  14. Kan, C. N., Gyanwali, B., Hilal, S., Ng, K. P., Venketasubramanian, N., Chen, C. L. H., & Xu, X. (2020). Neuropsychiatric Correlates of Small Vessel Disease Progression in Incident Cognitive Decline: Independent and Interactive Effects. Journal of Alzheimer's Disease, 73(3), 1053-1062.
    DOI: 10.3233/JAD-190999
  15. Gyanwali, B., Hilal, S., Venketasubramanian, N., Chen, C., & Loo, J. H. Y. (2020). Hearing handicap in Asian patients with dementia. American Journal of Otolaryngology, 41(2), 102-377.
    DOI: 10.1016/j.amjoto.2019.102377
  16. Tan, C. H., Hilal, S., Xu, X., Vrooman, H., Cheng, C. Y., Wong, T. Y., Venketasubramanim, N., & Chen, C. (2020). MRI Markers of Mixed Pathology and Cognitive Impairment in Multiethnic Asians. Journal of Alzheimer's Disease, (Preprint), 1-9.
    DOI: 10.3233/JAD-190866
  17. Venketasubramanian, N., Moorakonda, R. B., Lu, Q., Chen, C. L., & CHIMES Investigators. (2020). Frequency and Clinical Impact of Serious Adverse Events on Post-Stroke Recovery with NeuroAiD (MLC601) versus Placebo: The CHInese Medicine Neuroaid Efficacy on Stroke Recovery Study. Cerebrovascular Diseases, 49(2), 192-199.
    DOI: 10.1159/000506070
  18. Wong, L. C. K., Wong, M. Y. Z., Tan, C. S., Vrooman, H., Venketasubramanian, N., Cheng, C. Y., Chen, C., & Hilal, S. (2020). Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study. Scientific Reports (Nature Publisher Group), 10(1).
    DOI: 10.1038/s41598-020-59618-8
  19. Hilal, S., Biesbroek, M., Vrooman, H., Chong, E., Kuijf, H. J., Venketasubramanian, N., Cheng, C. Y., Wong, T. Y., Biessels, G. J., & Chen, C. (2020). The impact of strategic white matter hyperintensity lesion location on language. The American Journal of Geriatric Psychiatry.
    DOI: 10.1016/j.jagp.2020.06.009
  20. Boomsma, J. M. F., Exalto, L. G., Barkhof, F., Chen, C. L. H., Hilal, S., Leeuwis, A. E., Prins, N. D., Saridin, F. N., Scheltens, P., Teunissen, C. E., Verwer, J. H., Weinstein, H. C., van der Flier, W. M., Biessels, G. J., & TRACE‐VCI study group. (2020). Prediction of poor clinical outcome in vascular cognitive impairment: TRACE‐VCI study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 12(1), e12077.
  21. Mok, V. C. T., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P. M., Biessels, G. J., Chen, C., Cordonnier, C., Dichgans, M., Dominguez, J., Gorelick, P. B., Kim, S., Kwok, T., Greenberg, S. M., Jia, J., Kalaria, R., Kivipelto, M., Naegandran, K., Lam, L. C. W., Lam, B. Y. K., Lee, A. T. C, Markus, H. S., O'Brien, J., Pai, M. C., Pantoni, L., Sachdev, P., Skoog, I., Smith, E. E., Srikanth, V., Suh, G. H., Wardlaw, J., Ko, H., Black, S. E., & Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future. Alzheimer's & Dementia, 16(11), 1571-1581.
    DOI: 10.1002/alz.12143
  22. Knol, M. J., Lu, D., Traylor, M., Adams, H. H., Rafael, J., Romero, J., Smith, A. V., Fornage, M., Hofer, E., Liu, J., Hostettler, I. C., Luciano, M., Trompet, S., Giese, A. K., Hilal, S., van den Akker, E. B., Vojinovic, D., Li, S., Sigurdsson, S., van der Lee, S. J., Jack, C. R. Jr Wilson, D., Yilmaz, P., Satizabal, C. L., Liewald, D. C. M., van der Grond, J., Chen, C., Saba, Y., van der Lugt, A., Bastin, M. E., Windham, B. G., Cheng, C. Y., Pirpamer, L., Kantarci, K., Himali, J. J., Yang, Q., Morris, Z., Beiser, A. S., Tozer, D. J., Vernooij, M. W., Amin, N., Beekman, M., Koh, J. Y., Stott, D. J., Houlden, H., Schmidt, R., Gottesman, R. F., MacKinnon, A. D., DeCarli, C., Gudnason, V., Deary, I. J., van Duijn, C. M., Slagboom, P. E., Wong, T. Y., Rost, N. S., Jukema, J. W., Mosley, T. H., Werring, D. J., Schmidt, H., Wardlaw, J. M., Ikram, M. A., Seshadri, S., Launer, L. J., Markus, H. S. & Alzheimer's Disease Neuroimaging Initiative. (2020). Association of common genetic variants with brain microbleeds: A Genome-wide Association Study. Neurology, 95(24), e3331-e3343.
    DOI: 10.1212/WNL.0000000000010852
  23. Saridin, F. N., Hilal, S., Villaraza, S. G., Reilhac, A., Gyanwali, B., Tanaka, T., Stephenson, M. C., Ng, S. L., Vrooman, H., van der Flier, W. M., & Chen, C. L. H. (2020). Brain amyloid β, cerebral small vessel disease, and cognition: a memory clinic study. Neurology, 95(21), e2845-e2853.
    DOI: 10.1212/WNL.000000000001102
  24. Chua, J., Hu, Q., Ke, M., Tan, B., Hong, J., Yao, X., Hilal, S., Venketasubramanian, N., Garhöfer, G., Cheung, C. Y., Wong, T. Y., Chen, C. L., & Schmetterer, L. (2020). Retinal microvasculature dysfunction is associated with Alzheimer’s disease and mild cognitive impairment. Alzheimer's Research & Therapy, 12(1), 1-13.
    DOI: 10.1186/s13195-020-00724-0
  25. Lim, L. S., Matsumura, S., Htoon, H. M., Tian, J., Lim, S. B., Sensaki, S., Chen, C., Hilal, S., Wong, T. Y., Cheng, C. Y., Kuo, A., & Saw, S. M. (2020). MRI of posterior eye shape and its associations with myopia and ethnicity. British Journal of Ophthalmology, 104(9), 1239-1245.
    DOI: 10.1136/bjophthalmol-2019-315020
  26. Poh, L., Fann, D. Y., Wong, P., Lim, H. M., Foo, S. L., Kang, S. W., Rajeev, V., Selvaraji, S., Iyer, V. R., Parathy, N., Khan, M. B., Hess, D. C., Jo, D. G., Drummond, G. R., Sobey, C. G., Lai, M. K. P., Chen, C. L., Lim, L. H. K., & Arumugam, T. V. (2020). AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia. Molecular Psychiatry, 1-17.
    DOI: 10.1038/s41380-020-00971-5
  27. Vu, T. A., Fenwick, E. K., Gan, A. T., Man, R. E., Tan, B. K., Gupta, P., Ho, K. C., Reyes-Ortiz, C. A., Trompet, S., Gussekloo, J., O'Brien, J. M., Mueller-Schotte, S., Wong, T. Y., Tham, Y. C., Cheng, C. Y., Lee, A. T., Rait, G., Swenor, B. K., Varadaraj, V., Brenowitz, W. D., Medeiros, F. A., Naël, V., Narasimhalu, K., Chen, C. L., & Lamoureux, E. L. (2020). THE BIDIRECTIONAL RELATIONSHIP BETWEEN VISION AND COGNITION: A SYSTEMATIC REVIEW AND META-ANALYSIS. Ophthalmology.
    DOI: 10.1016/j.ophtha.2020.12.010

Year 2019 -

  1. Chan V. T. T., Sun Z., Tang S., Chen L. J., Wong A., Tham C. C., Wong T. Y., Chen C., Ikram M. K., Whitson H. E., Lad E. M., Mok V. C. T., Cheung C. Y. (2019). Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis. Ophthalmology 126 (2019) 497-510.
    DOI: 10.1016/j.ophtha.2018.08.009
  2. Cummings J., Passmore P., McGuinness B., Mok V., Chen C., Engelborghs S., Woodward M., Manzano S., Garcia-Ribas G., Cappa S., Bertolucci P., Chu L. W. (2019). Souvenaid in the management of mild cognitive impairment: an expert consensus opinion. Alzheimer's Research & Therapy 11 (2019) 73.
    DOI: 10.1186/s13195-019-0528-6
  3. Yasuda K., Maki T., Saito S., Yamamoto Y., Kinoshita H., Choi Y. K., Arumugam T. V., Lim Y. A., Chen C. L. H., Wong P. T., Ihara M., Takahashi R. (2019). Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion Brain Research 1720 (2019) 146294.
    DOI: 10.1016/j.brainres.2019.06.013
  4. Lo J. W., Crawford J. D., Desmond D. W., Godefroy O., Jokinen H., Mahinrad S., Bae H. J., Lim J. S., Köhler S., Douven E., Staals J., Chen C., Xu X., Chong E. J., Akinyemi R. O., Kalaria R. N., Ogunniyi A., Barbay M., Roussel M., Lee B. C., Srikanth V. K., Moran C., Kandiah N, Chander R. J., Sabayan B., Jukema J. W., Melkas S., Erkinjuntti T., Brodaty H., Bordet R., Bombois S., Hénon H., Lipnicki D. M., Kochan N. A., Sachdev P. S. (2019); Stroke and Cognition (STROKOG) Collaboration. Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups. Neurology (2019).
    DOI: 10.1212/WNL.0000000000008612
  5. Chai, Y. L., Chong, J. R., Weng, J., Howlett, D., Halsey, A., Lee, J. H., Attems, J., Aarsland, D., Francis, P. T., Chen, C. P., & Lai, M. K. P. (2019). Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration. Brain Pathol, 29(1), 63-74.
    DOI: 10.1111/bpa.12631
  6. Chen, C., & Anderson, C. S. (2019). Does reducing blood pressure and cholesterol provide any HOPE for preventing cognitive decline and dementia? Neurology, 92(13), 593-594.
    DOI: 10.1212/WNL.0000000000007175
  7. Chen, C. L. H., Sharma, P. R., Tan, B. Y., Low, C., & Venketasubramanian, N. (2019). The Alzheimer's disease THErapy with NEuroaid (ATHENE) study protocol: Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild-to-moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine-A randomized, double-blind, placebo-controlled trial. Alzheimer's & Dementia (N Y), 5, 38-45.
    DOI: 10.1016/j.trci.2018.12.001
  8. Cheung, C. Y., Chan, V. T. T., Mok, V. C., Chen, C., & Wong, T. Y. (2019). Potential retinal biomarkers for dementia: what is new? Current opinion in Neurology, 32(1), 82-91.
    DOI: 10.1097/WCO.0000000000000645
  9. Dong, Y., Ling, M. T. Y., Ng, K. E. T., Wang, A., Wan, E. Y. S., Merchant, R. A., Venketasubramanian, N., Chen, C. L., Mahendran, R., & Collinson, S. L. (2019). The Clinical Utility of the TYM and RBANS in a One-Stop Memory Clinic in Singapore: A Pilot Study. Journal of Geriatric Psychiatry and Neurology, 32(2), 68-73.
    DOI: 10.1177/0891988718824034
  10. Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., Hofer, E., Trompet, S., Hilal, S., Smith, A. V., Jian, X., Malik, R., Traylor, M., Pulit, S. L., Amouyel, P., Mazoyer, B., Zhu, Y. C., Kaffashian, S., Schilling, S., Beecham, G. W., Montine, T. J., Schellenberg, G. D., Kjartansson, O., Guethnason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N., Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B. M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C. Y., Wong, T. Y., Ikram, M. K., van der Lee, S. J., Amin, N., Chouraki, V., DeStefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., DeCarli, C., Wardlaw, J. M., Hernandez, M., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Munoz Maniega, S., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H. W., Lemmens, R., Brodaty, H., Wright, M. J., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., van der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., van der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., von Sarnowski, B., Volker, U., Levi, C., Jimenez-Conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Meschia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Rothwell, P. M., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Wasssertheil-Smoller, S., Lee, J. M., Wong, Q., Mitchell, B. D., Rich, S. S., McArdle, P. F., Geerlings, M. I., van der Graaf, Y., de Bakker, P. I. W., Asselbergs, F. W., Srikanth, V., Thomson, R., McWhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-Jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T., Jr., Debette, S., Stroke Genetics Network, t. I. S. G. C. M. A. s. D. G. C., the Neurology Working Group of the Cohorts for, H., & Aging Research in Genomic Epidemiology, C. (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology.
    DOI: 10.1212/WNL.0000000000006851
  11. Gallart-Palau, X., Serra, A., Hase, Y., Tan, C. F., Chen, C. P., Kalaria, R. N., & Sze, S. K. (2019). Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease. Brain Pathol.
    DOI: 10.1111/bpa.12699
  12. Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., Kandiah, N., Chen, C. P., Kalaria, R. N., & Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Res Rev, 53, 100909.
    DOI: 10.1016/j.arr.2019.100909
  13. Gyanwali, B., Shaik, M. A., Tan, B. Y., Venketasubramanian, N., Chen, C., & Hilal, S. (2019). Risk Factors for and Clinical Relevance of Incident and Progression of Cerebral Small Vessel Disease Markers in an Asian Memory Clinic Population. J Alzheimers Dis, 67(4), 1209-1219.
    DOI: 10.3233/JAD-180911
  14. Ji, F., Pasternak, O., Ng, K. K., Chong, J. S. X., Liu, S., Zhang, L., Shim, H. Y., Loke, Y. M., Tan, B. Y., Venketasubramanian, N., Chen, C. L., & Zhou, J. H. (2019). White matter microstructural abnormalities and default network degeneration are associated with early memory deficit in Alzheimer's disease continuum. Sci Rep, 9(1), 4749.
    DOI: 10.1038/s41598-019-41363-2
  15. Smeijer, D., Ikram, M. K., & Hilal, S. (2019). Enlarged Perivascular Spaces and Dementia: A Systematic Review. Journal of Alzheimer's Disease, 72(1), 247-256.
    DOI: 10.3233/JAD-190527
  16. Jung, N. Y., Han, J. C., Ong, Y. T., Cheung, C. Y., Chen, C. P., Wong, T. Y., Kim, H. J., Kim, Y. J., Lee, J., Lee, J. S., Jang, Y. K., Kee, C., Lee, K. H., Kim, E. J., Seo, S. W., & Na, D. L. (2019). Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease. J Neurol Sci, 396, 94-101.
    DOI: 10.1016/j.jns.2018.10.025
  17. Kan, C. N., Zhang, L., Cheng, C. Y., Wong, T. Y., Venketasubramanian, N., Chen, C. L., & Xu, X. (2019). The Informant AD8 Can Discriminate Patients with Dementia From Healthy Control Participants in an Asian Older Cohort. J Am Med Dir Assoc, 20(6), 775-779.
    DOI: 10.1016/j.jamda.2018.11.023
  18. Kandiah, N., Ong, P. A., Yuda, T., Ng, L. L., Mamun, K., Merchant, R. A., Chen, C., Dominguez, J., Marasigan, S., Ampil, E., Nguyen, V. T., Yusoff, S., Chan, Y. F., Yong, F. M., Krairit, O., Suthisisang, C., Senanarong, V., Ji, Y., Thukral, R., & Ihl, R. (2019). Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761((R)). CNS Neurosci Ther, 25(2), 288-298.
    DOI: 10.1111/cns.13095
  19. Kim, J., Selvaraji, S., Kang, S. W., Lee, W. T., Chen, C. L., Choi, H., Koo, E. H., Jo, D. G., Leong Lim, K., Lim, Y. A., & Arumugam, T. V. (2019). Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain Behav Immun.
    DOI: 10.1016/j.bbi.2019.04.011
  20. Kuijf, H. J., Biesbroek, J. M., de Bresser, J., Heinen, R., Andermatt, S., Bento, M., Berseth, M., Belyaev, M., Cardoso, M. J., Casamitjana, A., Collins, D. L., Dadar, M., Georgiou, A., Ghafoorian, M., Jin, D., Khademi, A., Knight, J., Li, H., Llado, X., Luna, M., Mahmood, Q., McKinley, R., Mehrtash, A., Ourselin, S., Park, B. Y., Park, H., Park, S. H., Pezold, S., Puybareau, E., Rittner, L., Sudre, C. H., Valverde, S., Vilaplana, V., Wiest, R., Xu, Y., Xu, Z., Zeng, G., Zhang, J., Zheng, G., Chen, C., van der Flier, W., Barkhof, F., Viergever, M. A., & Biessels, G. J. (2019). Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities; Results of the WMH Segmentation Challenge. IEEE Trans Med Imaging.
    DOI: 10.1109/TMI.2019.2905770
  21. Lim, C. Z. J., Zhang, Y., Chen, Y., Zhao, H., Stephenson, M. C., Ho, N. R. Y., Chen, Y., Chung, J., Reilhac, A., Loh, T. P., Chen, C. L. H., & Shao, H. (2019). Subtyping of circulating exosome-bound amyloid beta reflects brain plaque deposition. Nat Commun, 10(1), 1144.
    DOI: 10.1038/s41467-019-09030-2
  22. Lum, Z. K., Suministrado, M. S. P., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2019). Medication compliance in Singaporean patients with Alzheimer's disease. Singapore Med J, 60(3), 154-160.
    DOI: 10.11622/smedj.2018076
  23. Gyanwali, B., Shaik, M. A., Tan, C. S., Vrooman, H., Venketasubramanian, N., Chen, C., Hilal, S. (2019). Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population. Aging (Albany NY), 11(22), 10581.
    DOI: 10.18632/aging.102478
  24. Lim, L. S., Matsumura, S., Htoon, H. M., Tian, J., Lim, S. B., Sensaki, S., Chen, C., Hilal, S., Wong, T. Y., Cheng, C. Y., Kuo, A., & Saw, S. M. (2019). MRI of posterior eye shape and its associations with myopia and ethnicity.
    DOI: 0.1136/bjophthalmol-2019-315020
  25. Smith, E. E., Biessels, G. J., De Guio, F., de Leeuw, F. E., Duchesne, S., During, M., Frayne, R., Ikram, M. A., Jouvent, E., MacIntosh, B. J., Thrippleton, M. J., Vernooij, M. W., Adams, H., Backes, W. H., Ballerini, L., Black, S. E., Chen, C., Corriveau, R., DeCarli, C., Greenberg, S. M., Gurol, M. E., Ingrisch, M., Job, D., Lam, B. Y. K., Launer, L. J., Linn, J., McCreary, C. R., Mok, V. C. T., Pantoni, L., Pike, G. B., Ramirez, J., Reijmer, Y. D., Romero, J. R., Ropele, S., Rost, N. S., Sachdev, P. S., Scott, C. J. M., Seshadri, S., Sharma, M., Sourbron, S., Steketee, R. M. E., Swartz, R. H., van Oostenbrugge, R., van Osch, M., van Rooden, S., Viswanathan, A., Werring, D., Dichgans, M., & Wardlaw, J. M. (2019). Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Alzheimers Dement (Amst), 11, 191-204
    DOI: 10.1016/j.dadm.2019.01.002
  26. Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., Markus, H. S., Salman, R. A., Allan, S. M., Quinn, T. J., Kalaria, R. N., Werring, D. J., Carare, R. O., Touyz, R. M., Williams, S. C. R., Moskowitz, M. A., Katusic, Z. S., Lutz, S. E., Lazarov, O., Minshall, R. D., Rehman, J., Davis, T. P., Wellington, C. L., Gonzalez, H. M., Yuan, C., Lockhart, S. N., Hughes, T. M., Chen, C. L. H., Sachdev, P., O'Brien, J. T., Skoog, I., Pantoni, L., Gustafson, D. R., Biessels, G. J., Wallin, A., Smith, E. E., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, M. M. B., Roman, G. C., Hamel, E., Seshadri, S., Gottesman, R. F., van Buchem, M. A., Arvanitakis, Z., Schneider, J. A., Drewes, L. R., Hachinski, V., Finch, C. E., Toga, A. W., Wardlaw, J. M., & Zlokovic, B. V. (2019). Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement, 15(1), 158- 167.
    DOI: 10.1016/j.jalz.2018.07.222
  27. Weaver, N. A., Zhao, L., Biesbroek, J. M., Kuijf, H. J., Aben, H. P., Bae, H. J., Caballero, M. A. A., Chappell, F. M., Chen, C., Dichgans, M., Duering, M., Georgakis, M. K., van der Giessen, R. S., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Vom Hofe, E. M., de Kort, P. L. M., Koudstaal, P. J., Lam, B. Y. K., Lim, J. S., Makin, S. D. J., Mok, V. C. T., Shi, L., Valdes Hernandez, M. C., Venketasubramanian, N., Wardlaw, J. M., Wollenweber, F. A., Wong, A., Xin, X., Meta, V. C. I. M. c., & Biessels, G. J. (2019). The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimers Dement (Amst), 11, 310-326.
    DOI: 10.1016/j.dadm.2019.02.007
  28. Yatawara, C., Lee, D., Ng, K. P., Chander, R., Ng, D., Ji, F., Shim, H. Y., Hilal, S., Venketasubramanian, N., Chen, C., Zhou, J., & Kandiah, N. (2019). Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease. Am J Geriatr Psychiatry.
    DOI: 10.1016/j.jagp.2019.04.004
  29. Gyanwali, B., Shaik, M. A., Tan, C. S., Vrooman, H., Venketasubramanian, N., Chen, C., Hilal, S. (2019). Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population. Aging. 2019;11:10581-10596.
    DOI: 10.18632/aging.102478
  30. Yassi, N., Hilal, S., Xia, Y., Lim, Y. Y., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P. M., Masters, C. L. (2019). Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer's Disease. J Alzheimers Dis. 2019.
    DOI: 10.3233/JAD-191028
  31. Wilson, D., Ambler, G., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martinez-Domeno, A., Inamura, S., Yoshifuji, K., Arsava, E. M., Horstmann, S., Purrucker, J., Lam, B. Y. K., Wong, A., Kim, Y. D., Song, T. J., Schrooten, M., Lemmens, R., Eppinger, S., Gattringer, T., Uysal, E., Tanriverdi, Z., Bornstein, N. M., Assayag, E. B., Hallevi, H., Tanaka, J., Hara, H., Coutts, S. B., Hert, L., Polymeris, A., Seiffge, D. J., Lyrer, P., Algra, A., Kappelle, J., Al-Shahi Salman, R., Jager, H. R., Lip, G. Y. H., Mattle, H. P., Panos, L. D., Mas, J. L., Legrand, L., Karayiannis, C., Phan, T., Gunkel, S., Christ, N., Abrigo, J., Leung, T., Chu, W., Chappell, F., Makin, S., Hayden, D., Williams, D. J., Kooi, M. E., van Dam-Nolen, D. H. K., Barbato, C., Browning, S., Wiegertjes, K., Tuladhar, A. M., Maaijwee, N., Guevarra, C., Yatawara, C., Mendyk, A. M., Delmaire, C., Kohler, S., van Oostenbrugge, R., Zhou, Y., Xu, C., Hilal, S., Gyanwali, B., Chen, C., Lou, M., Staals, J., Bordet, R., Kandiah, N., de Leeuw, F. E., Simister, R., van der Lugt, A., Kelly, P. J., Wardlaw, J. M., Soo, Y., Fluri, F., Srikanth, V., Calvet, D., Jung, S., Kwa, V. I. H., Engelter, S. T., Peters, N., Smith, E. E., Yakushiji, Y., Orken, D. N., Fazekas, F., Thijs, V., Heo, J. H., Mok, V., Veltkamp, R., Ay, H., Imaizumi, T., Gomez-Anson, B., Lau, K. K., Jouvent, E., Rothwell, P. M., Toyoda, K., Bae, H. J., Marti-Fabregas, J., Werring, D. J., & Microbleeds International Collaborative, N. (2019). Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol.
    DOI: 10.1016/S1474-4422(19)30197-8
  32. Xu, X., Phua, A., Collinson, S. L., Hilal, S., Ikram, M. K., Wong, T. Y., Cheng, C. Y., Venketasubramanian, N., Chen, C. (2019). Additive effect of cerebral atrophy on cognition in dementia-free elderly with cerebrovascular disease. Stroke Vasc Neurol 2019;4:135-140.
    DOI: 10.1136/svn-2018-000202
  33. van der Lee, S. J., Knol, M. J., Chauhan, G., Satizabal, C. L., Smith, A. V., Hofer, E., Bis, J. C., Hibar, D. P., Hilal, S., van den Akker, E. B., Arfanakis, K., Bernard, M., Yanek, L. R., Amin, N., Crivello, F., Cheung, J. W., Harris, T. B., Saba, Y., Lopez, O. L., Li, S., van der Grond, J., Yu, L., Paus, T., Roshchupkin, G. V., Amouyel, P., Jahanshad, N., Taylor, K. D., Yang, Q., Mathias, R. A., Boehringer, S., Mazoyer, B., Rice, K., Cheng, C. Y., Maillard, P., van Heemst, D., Wong, T. Y., Niessen, W. J., Beiser, A. S., Beekman, M., Zhao, W., Nyquist, P. A., Chen, C., Launer, L. J., Psaty, B. M., Ikram, M. K., Vernooij, M. W., Schmidt, H., Pausova, Z., Becker, D. M., De Jager, P. L., Thompson, P. M., van Duijn, C. M., Bennett, D. A., Slagboom, P. E., Schmidt, R., Longstreth, W. T., Ikram, M. A., Seshadri, S., Debette, S., Gudnason, V., Adams, H. H. H., DeCarli, C. (2019). A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol 2019;2:285
    DOI: 10.1038/s42003-019-0537-9
  34. Gyanwali, B., Vrooman, H., Venketasubramanian, N., Wong, T. Y., Cheng, C. Y., Chen, C., Hilal, S. (2019). Cerebral Small Vessel Disease and Enlarged Perivascular Spaces-Data From Memory Clinic and Population-Based Settings. Front Neurol 2019;10:669.
    DOI: 10.3389/fneur.2019.00669
  35. Wong, M. Y. Z., Tan, C. S., Venketasubramanian, N., Chen, C., Ikram, M. K., Cheng, C. Y., Hilal, S. (2019). Prevalence and Risk Factors for Cognitive Impairment and Dementia in Indians: A Multiethnic Perspective from a Singaporean Study. J Alzheimers Dis 2019;71:341-351.
    DOI: 10.3233/JAD-190610
  36. Chan, V. T. T., Sun, Z., Tang, S., Chen, L. J., Wong, A., Tham, C. C., Wong, T. Y., Chen, C., Ikram, M. K., Whitson, H. E., Lad, E. M., Mok, V. C. T., & Cheung, C. Y. (2019). Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis. Ophthalmology, 126(4), 497-510.
    DOI:10.1016/j.ophtha.2018.08.009
  37. Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V., Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C. Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B. C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J. J. , Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R. Jr, Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T. Jr, Ikram, M. K., Smoller, J. W., van Tol, M. J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J. L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van 't Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S., Ikram, M. A. (2019). Nat Genet 2019; Genetic architecture of subcortical brain structures in 38,851 individuals.
    DOI: 10.1038/s41588-019-0511-y
  38. Charidimou, A., Zonneveld, H. I., Shams, S., Kantarci, K., Shoamanesh, A., Hilal, S., Yates, P. A., Boulouis, G., Na, H. K., Pasi, M., Biffi, A., Chai, Y. L., Chong, J. R., Wahlund, L. O., Clifford, L. R., Chen, C., Gurol, M. E., Goldstein, J. N., Na, D. L., Barkhof, F., Seo, S. W., Rosand, J., Greenberg, S. M., Viswanathan, A. (2019). APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms. Neurology 2019; 93:e358-e371.
    DOI: 10.1212/WNL.0000000000007818

Year 2018 -

  1. Chan, E. S., Chen, C., Soong, T. W., & Wong, B. S. (2018). Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples. Neuromolecular Med, 20(1), 124-132.
    DOI: 10.1007/s12017-018-8480-3
  2. Chai, Y. L., Xing, H. Y., Chong, J. R., Francis, P. T., Ballard, C. G., Chen, C. P., Lai, M. K. (2018). Mitochondrial Translocase of the Outer Membrane (TOM) Alterations may Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's disease. J Alzheimer's Disease 61 (2018) 793-801.
    DOI: 10.3233/JAD-170613
  3. Chanranarong, N., Chen, C., Lee, C. F., Young, S., Tay, S., Umapathi, T., Lao, A., Gan, H., Baroque II, A., Navarro, J., Chang, H., Joel Advincula, Muengtaweepongsa, S., Chan, B., Chua, C., Wijekoon, N., Silva, A., Hiyadan, J. H. B., Wong, K. S. L., Poungvarin, N., Eow, G., Venketasubramanian, N. (2018). Effect of combined treatment with MLC601 (NeuroAiD) and Rehabilitation on Post-Stroke Recovery – The CHIMES and CHIMES-E studies. Cerebrovascular Disease.
    DOI: 10.1159/000492625
  4. Cheung, C., Whitson, H. E., Lad, E., Tham, C., Chen, L. J., Chen, C., Tang, S., Wong, T., Chan, V. T. T., Sun, Z. H., Wong, A., Mok, V., Ikram, M. K. (2018). Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer's Disease: A Systematic Review and Metaanalysis. Ophthalmology.
    DOI: 10.1016/j.ophtha.2018.08.009
  5. Chen, C. P. L. H. and Mok, V. C. T. (2018). Marriage and risk of dementia: systematic review and meta-analysis of observational studies. JNeurology Neurosurgery & Psychiatry 89 (2018) 227.
    DOI: 10.1136/jnnp-2017-317178
  6. Chew, W. S., Seow, W. L., Chong, J. R., Lai, M. K. P., Torta, F., Wenk, M. R., Herr, D. R. (2018). Sphingolipidomics analysis of large clinical cohorts. Part 1: Technical notes and practical considerations. Biochemical and biophysical research communications. 2018.
    DOI: 10.1016/j.bbrc.2018.04.076
  7. Chong, J. R., Xiang, P., Wang, W., Hind, T., Chew, W. S., Ong, W. Y., Lai, M. K. P., Herr, D. R. (2018). Sphingolipidomics analysis of large clinical cohorts. Part 2: Potential impact and applications. Biochemical and biophysical research communications. 2018.
    DOI: 10.1016/j.bbrc.2018.04.075
  8. Fann, D. Y., Cheng, Y., Lok, K., Chunduri, P., Drummond, G. R., Lim, Y. A., Chen, C. P., Baik, S., Sobey, C. G., Dheen, S. T., Jo, D., Arumugam, T. V. (2018). Evidence that NFκ-B and MAPKs Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke. Molecular Neurobiology 55 (2018) 1082-96.
    DOI: 10.1007/s12035-017-0394-9
  9. Gyanwali, B., Shaik, M. A., Hilal, S., Cano, J., Chen, C., Venketasubramanian, N. (2018). Prevalence and association of syphilis reactivity in an Asian memory clinic population. International Journal of STD & AIDS
    DOI: 10.1177/0956462418787627
  10. Hilal, S., Tan, C. S., Adams, H. H. H., Habes, M., Mok, V., Venketasubramanian, N., Hofer, E., Ikram, M. K., Abrigo, J., Vernooij, M. W., Chen, C. P. L. H., Hosten, N., Völzke, H., Grabe, H. J., Schmidt, R., Ikram, M. A. (2018). Enlarged perivascular spaces and cognition: a meta-analysis of five populationbased studies
    DOI: 10.1212/WNL.0000000000006079
  11. Lum, Z. K., Suministrado, M. S. P., Venketasubramanian, N., Ikram, M. K., Chen, C. (2018). Medication compliance in patients with Alzheimer's disease seen at the National University Hospital in Singapore. Singapore Medical Journal.
    DOI: 10.11622/smedj.2018076
  12. Lee, J. J. Y., Thompson, C. L., Shaik, M. A., Wan, E., Chen, C. L., Dong, Y. H. (2018). Service use, advance planning and lifestyle changes following cognitive screening in primary healthcare in Singapore. Int Psychogeriatr. 30 (2018) 139-145.
    DOI: 10.1017/S1041610217001971
  13. Phua, A. K. S., Hiu, S. K. W., Goh, W. K., Ikram, M. K., Venketasubramanian, N., Tan, B. Y., Chen, C. L. H., Xu, X. (2018). Low accuracy of brief cognitive tests in tracking longitudinal cognitive decline in an Asian elderly cohort. J Alzheimer's Disease 62 (2018) 409-416.
    DOI: 10.3233/JAD-170831
  14. Reilhac, A., Merida, I., Irace, Z., Stephenson, M. C., Weekes, A. A., Chen, C., Totman, J. J., Townsend, D. W., Fayad, H., Costes, N. (2018). Development and validation of a rebinner with rigid motion correction for the Siemens PET/MR scanner: Application to a large cohort of 11C-PIB scans. Journal of Nuclear Medicine (2018).
    DOI: 10.2967/jnumed.117.206375
  15. Skrobot, O. A., Black, S., Chen, C., DeCarli, C., Erkinjuntti, T., Ford, G. A., Kalaria, R. N., O'Brien, J., Pantoni, L., Pasquier, F., Roman, G. C., Wallin, A., Sachdev, P., Skoog, I., VICCCS group, BenShlomoo, Y., Passmore, A. P., Love, S., Kehoe, P. G. (2018). Progress towards standardised diagnosis of vascular cognitive impairment: guidelines from the vascular impairment of cognition classification consensus study (VICCCS). Alzheimer's & Dementia 14 (2018) 280-292.
    DOI: 10.1016/j.jalz.2017.09.007
  16. Tan, B., Venketasubramanian, N., Vrooman, H., Cheng, C. Y., Wong, T. Y., Ikram, M. K., Chen, C., Hilal, S. (2018). Homocysteine and Cerebral Atrophy - The Epidemiology of Dementia In Singapore study. J Alzheimer's Disease 62 (2018) 877-885.
    DOI: 10.3233/JAD-170796
  17. Thiagarajan, S., Shaik, M. A.; Venketasubramanian, N.; Hilal, S., Chen, C. (2018). Coronal CT is comparable to MR imaging in aiding diagnosis of dementia in a memory clinic in Singapore. Alzheimer Disease & Associated Disorders (2017).
    DOI: 10.1097/WAD.0000000000000227
  18. Vipin, A.; Loke, Y. M.; Liu, S.; Hilal, S.; Shim, H. Y.; Xu, X.; Tan, B. Y.; Venketasubramanian, N.; Chen, C. L. H.; Zhou, J. (2018). Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease. Alzheimer's Research & Therapy.
    DOI: 10.1186/s13195-018-0413-8
  19. Xu, X., Chan, Y. H., Chan, Q. L., Gyanwali, B., Hilal, S., Tan, B. Y., Ikram, M. K., Venketasubramanian, N., Chen, C. (2018). Global cerebrovascular burden and long-term clinical outcomes in Asian elderly across the spectrum of cognitive impairment. International Psychogeriatrics (2018).
    DOI: 10.1017/S1041610217002952
  20. Xu, X., Kan, C. N., Wong, T. Y., Cheng, C. Y., Ikram, M. K., Chen, C. L. H., Venketasubramanian, N. (2018). Caregiver-reported sleep disturbances are associated with behavioral and psychological symptoms in an Asian elderly cohort with cognitive impairment-no dementia.Journal of Geriatric Psychiatry and Neurology.
    DOI: 10.1177/0891988718758203
  21. Zhu, Y., Hilal, S., Chai, Y. L., Ikram, M. K., Venketasubramanian, N., Chen, C. P., Lai, M. K. (2018). Serum hepatocyte growth factor is associated with small vessel disease in Alzheimer's dementia. Frontiers in Aging Neuroscience 10 (2018) 8.
    DOI: 10.3389/fnagi.2018.00008
  22. Chan, E. S., Bautista, D. T., Zhu, Y., You, Y., Long, J. T., Li, W., & Chen, C. (2018). Traditional Chinese herbal medicine for vascular dementia. Cochrane Database Syst Rev, 12, CD010284.
    DOI: 10.1002/14651858.CD010284.pub2
  23. Suwanwela, N. C., Chen, C. L. H., Lee, C. F., Young, S. H., Tay, S. S., Umapathi, T., Lao, A. Y., Gan, H. H., Baroque Ii, A. C., Navarro, J. C., Chang, H. M., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P. L., Chua, C. L., Wijekoon, N., de Silva, H. A., Hiyadan, J. H. B., Wong, K. S. L., Poungvarin, N., Eow, G. B., Venketasubramanian, N., & Investigators, C.-E. S. (2018). Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMESE Studies. Cerebrovasc Dis, 46(1-2), 82-88.
    DOI: 10.1159/000492625
  24. Tan, B., Venketasubramanian, N., Vrooman, H., Cheng, C. Y., Wong, T. Y., Chen, C., & Hilal, S. (2018). Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of populationbased study. Alzheimers Res Ther, 10(1), 114.
    DOI: 10.1186/s13195-018-0440-5

Year 2017 -

  1. Baumgartner, R., Cho, W., Coimbra, A., Chen, C., Wang, Z., Struyk, A., Venketasubramanian, N., Low, M., Gargano, C., Zhao, F., Williams, D., Reese, T., Seah, S., Feng, D., Apreleva, S., Petersen, E., Evelhoch, J. L. (2017). Evaluation of an fMRI USPIO-based assay in healthy human volunteers. J Magn Reson Imaging. 2017 Jul;46(1):124-133.
    DOI: 10.1002/jmri.25499
  2. Chan, V. T. T., So, T. H. K., Tang, F., Mok, V., Chen, C., Wong, T. Y., Cheung, C. Y. (2017). Using Retinal Imaging to Study Dementia. J Visualised Experiments (2017).
    DOI: 10.3791/56137
  3. Cheung, C. Y., Ikram, M. K., Chen, C., Wong, T. Y. (2017). Imaging retina to study dementia and stroke. Prog Retin Eye Res. 2017 Mar; 57:89-107.
    DOI: 10.1016/j.preteyeres.2017.01.001
  4. Hilal, S., Xin, X., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2017). Intracranial stenosis in cognitive impairment and dementia. Journal of Cerebral Blood Flow & Metabolism, 37(6), 2262-2269.
    DOI: 10.1177/0271678X16663752
  5. Chong, J. R., Chai, Y. L., Lee, J. H., Howlett, D., Attems, J., Ballard, C. G., Aarsland, D., Francis, P. T., Chen, C. P., Lai, M. K. (2017). Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load. J Alzheimers Dis. 2017; 56(1):157-166.
    DOI: 10.3233/JAD-160781
  6. Chong, J. S. X., Liu, S., Loke, Y. M., Hilal, S., Ikram Mohammad, Xu, X., Tan, B. Y., Venketasubramanian, N., Chen, C., Zhou, J. (2017). Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease. Brain 140 (2017) 3012-3022.
    DOI: 10.1093/brain/awx224
  7. Datta, A., Chai, Y. L., Tan, J. M., Lee, J. H., Francis, P. T., Chen, C. P., Sze, S. K., Lai, M. K. P. (2017). An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias. Mol Brain. 10 (2017) 3.
    DOI: 10.1186/s13041-017-0316-9
  8. Lee, C., Low, C. Y., Wong, S. Y., Lai, M. K., & Tan, M. G. (2017). Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes. Scientific Reports, 7(1), 1-15.
    DOI: 10.1038/srep43651
  9. Han, S. H., Lee, J. H., Kim, S. Y., Park, K. W., Chen, C., Tripathi, M., Dash, A., Kubota, N. (2017). Donepezil 23 mg in Asian patients with moderate-to-severe Alzheimer's disease. Acta Neurol Scand. 2017 Feb; 135(2):252-256.
    DOI: 10.1111/ane.12571
  10. Hilal, S., Chai, Y. L., van Veluw, S., Shaik, M. A., Ikram, M. K., Venketasubramanian, N., Richards, A. M., Biessels, G. J., Chen, C. (2017). Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts. JAMA Neurol. 2017 Apr 1;74(4):403-410.
    DOI: 10.1001/jamaneurol.2016.5335
  11. Hilal, S., Mok, V., Youn, Y. C., Wong, A., Ikram, M. K., Chen, C. L. (2017). Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries. J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):669-674
    DOI: 10.1136/jnnp-2016-315324
  12. Hilal, S., Tan, C. S., Xin, X., Amin, S. M., Wong, T. Y., Chen, C., Venketasubramanian, N., Ikram, M. K. (2017). Prevalence of cognitive impairment and dementia in Malays – Epidemiology of Dementia in Singapore Study Current Alzheimer Research 14 (2017) 620-27.
    DOI: 10.2174/1567205012666151002123813
  13. Ji, F., Pasternak, O., Liu, S., Loke, Y. M., Choo, B. L., Hilal, S., Xu, X., Ikram, M. K., Venketasubramanian, N., Chen, C. L., Zhou, J. (2017). Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease. Alzheimers Res Ther. 9 (2017) 63.
    DOI: 10.1186/s13195-017-0292-4
  14. Kumar, J. R., Rajkumar, R., Jayakody, T., Marwari, S., Hong, J. M., Ma, S., Gundlach, A. L., Lai, M. K. P., Dawe, G. S. (2017). Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. British journal of pharmacology. 2017; 174(10):1061-1076.
    DOI: 10.1111/bph.13564
  15. Offner, H., Ihara, M., Schäbitz, W. R., & Wong, P. T. (2017). Stroke and other cerebrovascular diseases.
    DOI: 10.1016/j.neuint.2017.04.003
  16. Lee, W. T., Chen, C. L-H., Lim, Y. A. (2017). The Effects of MLC901 on Tau Phosphorylation Neuroreport 28 (2017) 1043-1048.
    DOI: 10.1097/WNR.0000000000000884
  17. Liu, Y. H., Chan, S. J., Pan, H. C., Bandla, A., King, N. K. K., Wong, P. T. H., Chen, Y. Y., Ng, W. H., Thakor, N. V., Liao, L. D. (2017). Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model. Neurophotonics. Oct;4(4):045002.
    DOI: 10.1117/1.NPh.4.4.045002
  18. Loh, E. H., Ong, Y. T., Venketasubramanian, N., Hilal, S., Thet, N., Wong, T. Y., Chen, C. P. L., Cheung, C. Y. (2017). Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-Domain Optical Coherence Tomography in Patients with Cognitive Impairment. Front Neurol. 8 (2017) 359.
    DOI: 10.3389/fneur.2017.00359
  19. Navarro, J. C., Chen, C. L., Lee, C. F., Gan, H. H., Lao, A. Y., Baroque, A. C. 2nd, Hiyadan, J. H., Chua, C. L., San Jose, M. C., Advincula, J. M., Venketasubramanian, N.; CHIMES and CHIMES-E Study Investigators. Durability of the beneficial effect of MLC601 (NeuroAiD™) on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies. Int J Stroke. 2017 Apr;12(3):285-291.
    DOI: 10.1177/1747493016676615
  20. Roxas, A., Mehndiratta, M. M., Bornstein, N., Macdonell, R., Lim, K. S., Ng, P. W., Dashzeveg, S., Mizusawa, H., Esmatullah, H., Wu, S. L., Chen, C., Kurniawan, M., Rha, J. H., Wasay, M., Poungvarin, N., Gunatilake, S., Thang, N. H. (2017). The professional practice and training of neurology in the Asian and Oceanian Region: A cross-sectional survey by the Asian and Oceanian Association of Neurology (AOAN). Journal of the Neurological Sciences 382 (2017)
    DOI: 10.1016/j.jns.2017.09.022
  21. Sachdev, P. S., Lo, J. W., Crawford, J. D., Mellon, L., Hickey, A., Williams, D., Bordet, R., Mendyk, A. M., Gelé, P., Deplanque, D., Bae, H. J., Lim, J. S., Brodtmann, A., Werden, E., Cumming, T., Köhler, S., Verhey, F. R., Dong, Y. H., Tan, H. H., Chen, C., Xin, X., Kalaria, R. N., Allan, L. M., Akinyemi, R. O., Ogunniyi, A., Klimkowicz-Mrowiec, A., Dichgans, M., Wollenweber, F. A., Zietemann, V., Hoffmann, M., Desmond, D. W., Linden, T., Blomstrand, C., Fagerberg, B., Skoog, I., Godefroy, O., Barbay, M., Roussel, M., Lee, B. C., Yu, K. H., Wardlaw, J., Makin, S. J., Doubal, F. N., Chappell, F. M., Srikanth, V. K., Thrift, A. G., Donnan, G. A., Kandiah, N., Chander, R. J., Lin, X., Cordonnier, C., Moulin, S., Rossi, C., Sabayan, B., Stott, D. J., Jukema, J. W., Melkas, S., Jokinen, H., Erkinjuntti, T., Mok, V. C., Wong, A., Lam, B. Y., Leys, D., Hénon, H., Bombois, S., Lipnicki, D. M., Kochan, N. A.; STROKOG. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst). 2017; 7:11-23. Published online 2016 Nov 18.
    DOI: 10.1016/j.dadm.2016.10.006
  22. Shaik, M. A., Venketasubramanian, N., Cheng, C. Y., Wong, T. Y., Vrooman, H., Ikram, M. K., Chen, C., Hilal, S. (2017). Ankle brachial index, MRI markers and cognition - The Epidemiology of Dementia in Singapore study. Atherosclerosis. 263 (2017) 272-277.
    DOI: 10.1016/j.atherosclerosis.2017.07.002
  23. Skrobot, O. A., O'Brien, J., Black, S., Chen, C., DeCarli, C., Erkinjuntti, T., Ford, G. A., Kalaria, R. N., Pantoni, L., Pasquier, F., Roman, G. C., Wallin, A., Sachdev, P., Skoog, I.; VICCCS group, BenShlomo, Y., Passmore, A. P., Love, S., Kehoe, P. G. (2017). The Vascular Impairment of Cognition Classification Consensus Study. Alzheimers Dement. 2017 Jun;13(6):624-633.
    DOI: 10.1016/j.jalz.2016.10.007
  24. Suministrado, M. S. P., Shuang, E. W. Y., Xu, J., Teoh, H. L., Chan, B. P., Venketasubramanian, N., Seet, R. C. S., Chen, C. L., Wong, B. S., Sharma, V. K., Dong, Y. (22017). Poststroke Cognitive Decline is Independent of Longitudinal Changes in Cerebral Hemodynamics Parameters. J Neuroimaging. 2017 May; 27(3):326-332.
    DOI: 10.1111/jon.12395
  25. Tan, H. H., Xu, J., Teoh, H. L., Chan, B. P., Seet, R. C., Venketasubramanian, N., Sharma, V. K., Chen, C. L., Dong, Y. (2017). Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation. PLoS One. 2017 Mar 27;12(3):e0173291.
    DOI: 10.1371/journal.pone.0173291
  26. Tan, J. R., Tan, K. S., Yong, F. L., Armugam, A., Wang, C. W., Jeyaseelan, K., Wong, P. T. (2017). MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. PLoS One. Feb 15;12(2):e0172131.
    DOI: 10.1371/journal.pone.0172131
  27. Ting, S. K. S., Earnest, A., Lid, H., Hameed, S., Chang, H. M., Chen, C. L. H., Tan, E. K. (2017). B Vitamins and Cognition in subjects with small vessel disease: An extension study of VITATOPS, A Randomised, Placebo-Controlled Trial. J Neurol Sci 379 (2017) 124-126.
    DOI: 10.1016/j.jns.2017.05.061
  28. van Veluw, S. J., Shih, A. Y., Smith, E. E., Chen, C., Schneider, J. A., Wardlaw, J. M., Greenberg, S. M., Biessels, G. J. (2017). Detection, risk factors, and functional consequences of cerebral microinfarcts. Lancet Neurology 16 (2017) 730-40.
    DOI: 10.1016/S1474-4422(17)30196-5
  29. Venketasubramanian N, Lee, C. F., Young, S. H., Tay, S. S., Umapathi, T., Lao, A. Y., Gan, H. H., Baroque Ii, A. C., Navarro, J. C., Chang, H. M., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P., Chua, C. L., Wijekoon, N., de Silva, H. A., Hiyadan, J. H., Suwanwela, N. C., Wong, K. S., Poungvarin, N., Eow, G. B., Chen, C. L.; CHIMES-E Study Investigators. (2017). Prognostic Factors and Pattern of Long-Term Recovery with MLC601 (NeuroAiD™) in the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study. Cerebrovasc Dis. 2017;43(1-2):36-42.
    DOI: 10.1159/000452285
  30. Xu, X., Chan, Q. L., Hilal, S., Goh, W. K., Ikram, M. K., Wong, T. Y., Cheng, C. Y., Chen, C. L., Venketasubramanian, N. (2017). Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort. J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):7-11.
    DOI: 10.1136/jnnp-2016-313271
  31. Yang, Y. H., Meguro, K., Dominguez, J., Chen, C. L., Wang, H., Ong, P. A. (2019). Gender's Effects to the Early Symptoms of Alzheimer's Disease in 5 Asian Countries. Am J Alzheimers Dis Other Demen. 2017 Jun;32(4):194-199.
    DOI: 10.1177/1533317517698796
  32. Zhu, Y., Chai, Y. L., Hilal, S., Ikram, M. K., Venketasubramanian, N., Wong, B. S., Chen, C. P., Lai, M. K. (2017). Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease. Alzheimers Dement (Amst). 2017; 7:41-47. Published onlined 2017 Jan 23.
    DOI: 10.1016/j.dadm.2017.01.001
  33. Hilal, S., Akoudad, S., van Duijn, C. M., Niessen, W. J., Verbeek, M. M., Vanderstichele, H., Stoops, E., Ikram, M. A., & Vernooij, M. W. (2017). Plasma Amyloid-beta Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study. J Alzheimers Dis, 60(3), 977-987.
    DOI: 10.3233/JAD-170458

Year 2016 -

  1. Adams, H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P. A., Renteria, M. E., Trompet, S., Arias-Vasquez, A., Seshadri, S., Desrivieres, S., Beecham, A. H., Jahanshad, N., Wittfeld, K., Van der Lee, S. J., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., Armstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R., Cuellar-Partida, G., Braber, A. D., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liao, J., Liewald, D. C., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., McKay, D. R., McWhirter, R., Milaneschi, Y., Mirza-Schreiber, N., Muetzel, R. L., Maniega, S. M., Nho, K., Nugent, A. C., Loohuis, L. M., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Putz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santianez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Samann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., Van der Grond, J., Van der Meer, D., Van Donkelaar, M. M., Van Eijk, K. R., Van Erp, T. G., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Geus, E. J., De Jager, P. L., de Zubicaray, G. I., Delanty, N., Depondt, C., DeStefano, A. L., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernandez, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Goring, H. H., Grabe, H. J., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Hulshoff Pol, H. E., Ikeda, M., Ikram, M. K., Jack, C. R., Jr., Jenkinson, M., Johnson, R., Jonsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaitre, H., Liu, X., Longo, D. L., Longstreth, W. T., Jr., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, K. L., McMahon, F. J., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Muhleisen, T. W., Muller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nothen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigurdsson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Hernandez, M. C., Van der Brug, M., Van der Lugt, A., Van der Wee, N. J., Van Duijn, C. M., Van Haren, N. E., Van, T. E. D., Van Tol, M. J., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Volzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, H. R., Zonderman, A. B., Deary, I. J., DeCarli, C., Schmidt, H., Martin, N. G., De Craen, A. J., Wright, M. J., Launer, L. J., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A., & Thompson, P. M. (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci, 19(12), 1569-1582.
    DOI: 10.1038/nn.4398
  2. Biesbroek, J. M., Weaver, N. A., Hilal, S., Kuijf, H. J., Ikram, M. K., Xu, X., Tan, B. Y., Venketasubramanian, N., Postma, A., Biessels, G. J., & Chen, C. P. (2016). Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease. PLoS One, 11(11), e0166261.
    DOI: 10.1371/journal.pone.0166261
  3. Chai, Y. L., Hilal, S., Chong, J. P., Ng, Y. X., Liew, O. W., Xu, X., Ikram, M. K., Venketasubramanian, N., Richards, A. M., Lai, M. K., & Chen, C. P. (2016). Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia. Medicine (Baltimore), 95(33), e4566.
    DOI: 10.1097/MD.0000000000004566
  4. Chai, Y. L., Yeo, H. K., Wang, J., Hilal, S., Ikram, M. K., Venketasubramanian, N., Wong, B. S., & Chen, C. L. (2016). Apolipoprotein varepsilon4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A SingaporeBased Cohort. J Alzheimers Dis, 51(4), 1111-1118.
    DOI: 10.3233/JAD-150902
  5. Chan, E. S., Shetty, M. S., Sajikumar, S., Chen, C., Soong, T. W., & Wong, B. S. (2016). ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Abeta impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep, 6, 26119.
    DOI: 10.1038/srep26119
  6. Chan, Q. L., Shaik, M. A., Xu, J., Xu, X., Chen, C. L., & Dong, Y. (2016). The Combined Utility of a Brief Functional Measure and Performance-Based Screening Test for Case Finding of Cognitive Impairment in Primary Healthcare. J Am Med Dir Assoc, 17(4), 372 e379-311.
    DOI: 10.1016/j.jamda.2015.12.095
  7. Chan, Q. L., Xu, X., Shaik, M. A., Chong, S. S., Hui, R. J., Chen, C. L., & Dong, Y. (2016). Clinical utility of the informant AD8 as a dementia case finding instrument in primary healthcare. J Alzheimers Dis, 49(1), 121-127.
    DOI: 10.3233/JAD-150390
  8. Chen, C., Homma, A., Mok, V. C., Krishnamoorthy, E., Alladi, S., Meguro, K., Abe, K., Dominguez, J., Marasigan, S., Kandiah, N., Kim, S. Y., Lee, D. Y., De Silva, H. A., Yang, Y. H., Pai, M. C., Senanarong, V., & Dash, A. (2016). Alzheimer's disease with cerebrovascular disease: current status in the AsiaPacific region. J Intern Med, 280(4), 359-374.
    DOI: 10.1111/joim.12495
  9. De Guio, F., Jouvent, E., Biessels, G. J., Black, S. E., Brayne, C., Chen, C., Cordonnier, C., De Leeuw, F. E., Dichgans, M., Doubal, F., Duering, M., Dufouil, C., Duzel, E., Fazekas, F., Hachinski, V., Ikram, M. A., Linn, J., Matthews, P. M., Mazoyer, B., Mok, V., Norrving, B., O'Brien, J. T., Pantoni, L., Ropele, S., Sachdev, P., Schmidt, R., Seshadri, S., Smith, E. E., Sposato, L. A., Stephan, B., Swartz, R. H., Tzourio, C., van Buchem, M., van der Lugt, A., van Oostenbrugge, R., Vernooij, M. W., Viswanathan, A., Werring, D., Wollenweber, F., Wardlaw, J. M., & Chabriat, H. (2016). Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. J Cereb Blood Flow Metab, 36(8), 1319-1337.
    DOI: 10.1177/0271678X16647396
  10. Deng, Q. Q., Tang, J., Chen, C., Markus, H., Huang, Y. N., Zhao, H., Ratanakorn, D., Wong, K. S., & Fu, J. H. (2016). The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial. J Neurol Sci, 367, 18-21.
    DOI: 10.1016/j.jns.2016.05.042
  11. Dichgans, M., Wardlaw, J., Smith, E., Zietemann, V., Seshadri, S., Sachdev, P., Biessels, G. J., Fazekas, F., Benavente, O., & Pantoni, L. (2016). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's & Dementia, 12(12), 1235-1249.
    DOI: 10.1016/j.jalz.2016.06.004
  12. Dong, Y. (2016). Brain Health: Case Finding of Cognitive Impairment in Primary Care by Using a Risk Score and 2-Pronged Performance-based and Informant-based Assessment Approach. J Am Med Dir Assoc, 17(5), 460-461.
    DOI: 10.1016/j.jamda.2016.02.027
  13. Dong, Y., Xu, J., Chan, B. P., Seet, R. C., Venketasubramanian, N., Teoh, H. L., Sharma, V. K., & Chen, C. L. (2016). The Montreal Cognitive Assessment is superior to National Institute of Neurological Disease and Stroke-Canadian Stroke Network 5-minute protocol in predicting vascular cognitive impairment at 1 year. BMC Neurol, 16, 46
    DOI: 10.1186/s12883-016-0570-y
  14. Fabiana, N. L., Chen, C. L., Venketasubramanian, N., Lee, C. F., Wong, K. S., & De Silva, D. A. (2016). Sex and the treatment effect in the Chinese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) trial. J Clin Neurosci, 33, 269-270.
    DOI: 10.1016/j.jocn.2016.04.013
  15. Gallart-Palau, X., Lee, B. S., Adav, S. S., Qian, J., Serra, A., Park, J. E., Lai, M. K., Chen, C. P., Kalaria, R. N., & Sze, S. K. (2016). Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease. Mol Brain, 9, 27.
    DOI: 10.1186/s13041-016-0205-7
  16. Hilal, S., Sikking, E., Shaik, M. A., Chan, Q. L., van Veluw, S. J., Vrooman, H., Cheng, C. Y., Sabanayagam, C., Cheung, C. Y., Wong, T. Y., Venketasubramanian, N., Biessels, G. J., Chen, C., & Ikram, M. K. (2016). Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease. Neurology, 87(15), 1583-1590.
    DOI: 10.1212/WNL.0000000000003110
  17. Krishnan, K., Scutt, P., Woodhouse, L., Adami, A., Becker, J. L., Berge, E., Cala, L. A., Casado, A. M., Caso, V., Chen, C., Christensen, H., Collins, R., Czlonkowska, A., Dineen, R. A., Gommans, J., Koumellis, P., Lees, K. R., Ntaios, G., Ozturk, S., Phillips, S. J., Pocock, S. J., de Silva, A., Sprigg, N., Szatmari, S., Wardlaw, J. M., & Bath, P. M. (2016). Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. Stroke, 47(1), 44-52.
    DOI: 10.1161/STROKEAHA.115.010368
  18. Krishnan, K., Scutt, P., Woodhouse, L., Adami, A., Becker, J. L., Cala, L. A., Casado, A. M., Chen, C., Dineen, R. A., Gommans, J., Koumellis, P., Christensen, H., Collins, R., Czlonkowska, A., Lees, K. R., Ntaios, G., Ozturk, S., Phillips, S. J., Sprigg, N., Szatmari, S., Wardlaw, J. M., Bath, P. M., & Investigators, E. (2016). Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial. J Stroke Cerebrovasc Dis, 25(5), 1017-1026.
    DOI: 10.1016/j.jstrokecerebrovasdis.2016.01.010
  19. Kuo, A. N., Verkicharla, P. K., McNabb, R. P., Cheung, C. Y., Hilal, S., Farsiu, S., Chen, C., Wong, T. Y., Ikram, M. K., Cheng, C. Y., Young, T. L., Saw, S. M., & Izatt, J. A. (2016). Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. Invest Ophthalmol Vis Sci, 57(9), OCT196-203.
    DOI: 10.1167/iovs.15-18886
  20. Lee, C. F., Venketasubramanian, N., Wong, K. S., Chen, C. L., & Investigators, C. S. (2016). Comparison Between the Original and Shortened Versions of the National Institutes of Health Stroke Scale in Ischemic Stroke Patients of Intermediate Severity. Stroke, 47(1), 236-239.
    DOI: 10.1161/STROKEAHA.115.011657
  21. Lee, J. H., Francis, P. T., Ballard, C. G., Aarsland, D., Kalaria, R. N., Wong, P. T., Chen, C. P., & Lai, M. K. (2016). Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia. J Parkinsons Dis, 6(4), 733-739.
    DOI: 10.3233/JPD-160932
  22. Lee, J. H., Koh, S. Q., Guadagna, S., Francis, P. T., Esiri, M. M., Chen, C. P., Wong, P. T., Dawe, G. S., & Lai, M. K. (2016). Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients. Psychopharmacology (Berl), 233(4), 591-598.
    DOI: 10.1007/s00213-015-4131-7
  23. Liu, S., Ong, Y. T., Hilal, S., Loke, Y. M., Wong, T. Y., Chen, C. L., Cheung, C. Y., & Zhou, J. (2016). The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease. J Alzheimers Dis, 54(2), 585-595.
    DOI: 10.3233/JAD-160067
  24. Phua, A. K., Goh, W. K., Suministrado, S. P., Hilal, S., Ikram, M. K., Venketasubramanian, N., Xu, X., & Chen, C. L. (2016). Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore. J Am Med Dir Assoc, 17(9), 863 e869-863 e814.
    DOI: 10.1016/j.jamda.2016.06.002
  25. Qiu, Y., Liu, S., Hilal, S., Loke, Y. M., Ikram, M. K., Xu, X., Yeow Tan, B., Venketasubramanian, N., Chen, C. L., & Zhou, J. (2016). Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI. Sci Rep, 6, 32573.
    DOI: 10.1038/srep32573
  26. Shaik, M. A., Chan, Q. L., Xu, J., Xu, X., Hui, R. J., Chong, S. S., Chen, C. L., & Dong, Y. (2016). Risk Factors of Cognitive Impairment and Brief Cognitive Tests to Predict Cognitive Performance Determined by a Formal Neuropsychological Evaluation of Primary Health Care Patients. J Am Med Dir Assoc, 17(4), 343-347.
    DOI: 10.1016/j.jamda.2015.12.007
  27. Shaik, M. A., Khoo, C. H., Thiagarajah, A. G., Tan, N. C., Li-Hsian Chen, C., Xu, J., & Dong, Y. (2016). Pilot Evaluation of a Dementia Case Finding Clinical Service Using the Informant AD8 for At-Risk Older Adults in Primary Health Care: A Brief Report. J Am Med Dir Assoc, 17(7), 673 e675-678.
    DOI: 10.1016/j.jamda.2016.04.027
  28. Shaik, M. A., Xu, X., Chan, Q. L., Hui, R. J., Chong, S. S., Chen, C. L., & Dong, Y. (2016). The reliability and validity of the informant AD8 by comparison with a series of cognitive assessment tools in primary healthcare. Int Psychogeriatr, 28(3), 443-452.
    DOI: 10.1017/S1041610215001702
  29. Shuang Wan, E. Y., Shaik, M. A., Adhha, A., Hoo Ng, R. M., Thompson, C., Ong, I., Xu, J., Li-Hsian Chen, C., & Dong, Y. (2016). Pilot Evaluation of the Informant AD8 as a Case-Finding Instrument for Cognitive Impairment in General Practitioner Clinics of Singapore: A Brief Report. J Am Med Dir Assoc, 17(12), 1147-1150.
    DOI: 10.1016/j.jamda.2016.07.031
  30. Xing, H., Lim, Y. A., Chong, J. R., Lee, J. H., Aarsland, D., Ballard, C. G., Francis, P. T., Chen, C. P., & Lai, M. K. (2016). Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with beta-amyloid burden and synaptic deficits in Lewy body dementias. Mol Brain, 9(1), 84.
    DOI: 10.1186/s13041-016-0264-9
  31. Xu, X., Chan, Q. L., Hilal, S., Ikram, M. K., Venketasubramanian, N., Tan, B. Y., Dong, Y., Chen, C. L., & Collinson, S. L. (2016). The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics. Dement Geriatr Cogn Dis Extra, 6(2), 276-282.
    DOI: 10.1159/000445050
  32. Xu, X., Hilal, S., Collinson, S. L., Chan, Q. L., Yi Chong, E. J., Ikram, M. K., Venketasubramanian, N., Cheng, C. Y., Wong, T. Y., & Chen, C. L. (2016). Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample. J Alzheimers Dis, 52(3), 1021-1028.
    DOI: 10.3233/JAD-160139
  33. Yang, Y. H., Meguro, K., Kim, S. Y., Shim, Y. S., Yu, X., Chen, C. L., Wang, H., Lam, L., Senanarong, V., Dominguez, J., Lu, P. Y., Lin, Y. T., Hu, C. J., Chiu, P. Y., Fuh, J. L., Wang, W. F., Yu, B. C., Li, T., Wang, M. W., Situmeang, R. F., Jang, J. W., Zhang, J., Chan, W. C., Zhou, Y. Y., Lou, H. L., Zhang, L., Ye, M., & Chen, X. (2016). Impact of Alzheimer's Disease in Nine Asian Countries. Gerontology, 62(4), 425-433.
    DOI: 10.1159/000443525

Year 2015 -

  1. Adams, H. H., Hilal, S., Schwingenschuh, P., Wittfeld, K., van der Lee, S. J., DeCarli, C., Vernooij, M. W., Katschnig-Winter, P., Habes, M., Chen, C., Seshadri, S., van Duijn, C. M., Ikram, M. K., Grabe, H. J., Schmidt, R., & Ikram, M. A. (2015). A priori collaboration in population imaging: The Uniform NeuroImaging of Virchow-Robin Spaces Enlargement consortium. Alzheimers Dement (Amst), 1(4), 513- 520
    DOI: 10.1016/j.dadm.2015.10.004
  2. Chan, E. S., Chen, C., Cole, G. M., & Wong, B. S. (2015). Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Sci Rep, 5, 13842.
    DOI: 10.1038/srep13842
  3. Chan, Q. L., Xu, X., Shaik, M. A., Chong, S. S. T., Hui, R. J. Y., Chen, C. L.-H., & Dong, Y. (2016). Clinical utility of the informant AD8 as a dementia case finding instrument in primary healthcare. Journal of Alzheimer's Disease, 49(1), 121-127
    DOI: 10.3233/JAD-150390
  4. Chankrachang, S., Navarro, J. C., de Silva, D. A., Towanabut, S., Chua, C. L., Lee, C. F., Venketasubramanian, N., Wong, K. S., Bousser, M. G., Chen, C. L., & Investigators, C. S. (2015). Prognostic factors and treatment effect in the CHIMES study. J Stroke Cerebrovasc Dis, 24(4), 823- 827.
    DOI: 10.1016/j.jstrokecerebrovasdis.2014.11.017
  5. Cheung, C. Y., Chen, C., & Wong, T. Y. (2015). Ocular Fundus Photography as a Tool to Study Stroke and Dementia. Semin Neurol, 35(5), 481-490.
    DOI: 10.1055/s-0035-1563570
  6. Cheung, C. Y., Ikram, M. K., Klein, R., & Wong, T. Y. (2015). The clinical implications of recent studies on the structure and function of the retinal microvasculature in diabetes. Diabetologia, 58(5), 871-885.
    DOI: 10.1007/s00125-015-3511-1
  7. Cheung, C. Y., Ong, Y. T., Hilal, S., Ikram, M. K., Low, S., Ong, Y. L., Venketasubramanian, N., Yap, P., Seow, D., Chen, C. L., & Wong, T. Y. (2015). Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis, 45(1), 45-56.
    DOI: 10.3233/JAD-141659
  8. Dong, Y., Koay, W. I., Yeo, L. L., Chen, C. L., Xu, J., Seet, R. C., & Lim, E. C. (2015). Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study. Parkinsons Dis, 2015, 348063.
    DOI: 10.1155/2015/348063
  9. Fabiana, N. L., Lee, C. F., Gan, R., Venketasubramanian, N., Wong, K. S., Bousser, M. G., Chen, C. P., De Silva, D. A., & Investigators, C. S. (2015). Using the full span of the SPAN-100 index to predict functional outcome in the CHIMES study. Int J Stroke, 10(2), E21.
    DOI: 10.1111/ijs.12405
  10. Gallart-Palau, X., Serra, A., Qian, J., Chen, C. P., Kalaria, R. N., & Sze, S. K. (2015). Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. Neurochem Int, 80, 87-98.
    DOI: 10.1016/j.neuint.2014.12.002
  11. Gallart-Palau, X., Serra, A., Wong, A. S., Sandin, S., Lai, M. K., Chen, C. P., Kon, O. L., & Sze, S. K. (2015). Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR). Sci Rep, 5, 14664.
    DOI: 10.1038/srep14664
  12. Hilal, S., Amin, S. M., Venketasubramanian, N., Niessen, W. J., Vrooman, H., Wong, T. Y., Chen, C., & Ikram, M. K. (2015). Subcortical Atrophy in Cognitive Impairment and Dementia. J Alzheimers Dis, 48(3), 813-823.
    DOI: 10.3233/JAD-150473
  13. Hilal, S., Chai, Y. L., Ikram, M. K., Elangovan, S., Yeow, T. B., Xin, X., Chong, J. Y., Venketasubramanian, N., Richards, A. M., Chong, J. P., Lai, M. K., & Chen, C. (2015). Markers of cardiac dysfunction in cognitive impairment and dementia. Medicine (Baltimore), 94(1), e297.
    DOI: 10.1097/MD.0000000000000297
  14. Hilal, S., Saini, M., Tan, C. S., Catindig, J. A., Dong, Y. H., Holandez, R. L., Niessen, W. J., Vrooman, H. A., Ting, E., Wong, T. Y., Chen, C., Venketasubramanian, N., & Ikram, M. K. (2015). Intracranial stenosis, cerebrovascular diseases, and cognitive impairment in chinese. Alzheimer Dis Assoc Disord, 29(1), 12-17.
    DOI: 10.1097/WAD.0000000000000045
  15. Hilal, S., Xin, X., Ang, S. L., Tan, C. S., Venketasubramanian, N., Niessen, W. J., Vrooman, H., Wong, T. Y., Chen, C., & Ikram, M. K. (2015). Risk Factors and Consequences of Cortical Thickness in an Asian Population. Medicine (Baltimore), 94(23), e852.
    DOI: 10.1097/MD.0000000000000852
  16. Howlett, D. R., Whitfield, D., Johnson, M., Attems, J., O'Brien, J. T., Aarsland, D., Lai, M. K., Lee, J. H., Chen, C., Ballard, C., Hortobagyi, T., & Francis, P. T. (2015). Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain Pathol, 25(4), 401-408.
    DOI: 10.1111/bpa.12182
  17. Investigators, E. T. (2015). Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The Lancet, 385(9968), 617-628.
    DOI: 10.1016/S0140-6736(14)61121-1
  18. Lim, S. L., Gao, Q., Nyunt, M. S. Z., Gong, L., Lunaria, J. B., Lim, M. L., Ling, A., Lam, C. S.-P., Richards, A. M., & Ling, L. H. (2016). Vascular health indices and cognitive domain function: Singapore longitudinal ageing studies. Journal of Alzheimer's Disease, 50(1), 27-40.
    DOI: 10.3233/JAD-150516
  19. Saini, M., Suministrado, M. S., Hilal, S., Dong, Y. H., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2015). Prevalence and Risk Factors of Acute Incidental Infarcts. Stroke, 46(10), 2722-2727.
    DOI: 10.1161/STROKEAHA.115.009963
  20. Mohamed, N. E., Lee, J. H., Francis, P. T., Esiri, M. M., Chen, C. P., & Lai, M. K. (2015). Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. J Alzheimers Dis, 44(2), 431-437.
    DOI: 10.3233/JAD-141764
  21. Narasimhalu, K., Lee, J., Leong, Y. L., Ma, L., De Silva, D. A., Wong, M. C., Chang, H. M., & Chen, C. (2015). Inflammatory markers and their association with post stroke cognitive decline. Int J Stroke, 10(4), 513-518.
    DOI: 10.1111/ijs.12001
  22. Narasimhalu, K., Ma, L., De Silva, D. A., Wong, M. C., Chang, H. M., & Chen, C. (2015). Elevated platelet-derived growth factor AB/BB is associated with a lower risk of recurrent vascular events in stroke patients. Int J Stroke, 10(1), 85-89.
    DOI: 10.1111/ijs.12358
  23. Natanegara, F., Tran, A., Lowe, S., Tham, L. S., & Chen, C. (2015). Estimation of the inter- and intrasubject variability of the diurnal serum cortisol rhythm in healthy male subjects to evaluate the biomarker potential for drug target engagement. Int J Clin Pharmacol Ther, 53(3), 199-205.
    DOI: 10.5414/CP202181
  24. Ng, D. S., Gupta, P., Tham, Y. C., Peck, C. F., Wong, T. Y., Ikram, M. K., & Cheung, C. Y. (2015). Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography. J Ophthalmol, 2015, 605940
    DOI: 10.1155/2015/605940
  25. Ng, W. Y., Tan, G. S., Ong, P. G., Cheng, C. Y., Cheung, C. Y., Wong, D. W., Mathur, R., Chow, K. Y., Wong, T. Y., & Cheung, G. C. (2015). Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy. Am J Ophthalmol, 159(3), 557-564 e551.
    DOI: 10.1016/j.ajo.2014.12.005
  26. Nizetic, D., Chen, C. L., Hong, W., & Koo, E. H. (2015). Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci, 9, 299.
    DOI: 10.3389/fnbeh.2015.00299
  27. Ong, Y. T., Hilal, S., Cheung, C. Y., Venketasubramanian, N., Niessen, W. J., Vrooman, H., Anuar, A. R., Chew, M., Chen, C., Wong, T. Y., & Ikram, M. K. (2015). Retinal neurodegeneration on optical coherence tomography and cerebral atrophy. Neurosci Lett, 584, 12-16.
    DOI: 10.1016/j.neulet.2014.10.010
  28. van Veluw, S. J., Hilal, S., Kuijf, H. J., Ikram, M. K., Xin, X., Yeow, T. B., Venketasubramanian, N., Biessels, G. J., & Chen, C. (2015). Cortical microinfarcts on 3T MRI: Clinical correlates in memoryclinic patients. Alzheimers Dement, 11(12), 1500-1509.
    DOI: 10.1016/j.jalz.2014.12.010
  29. Venketasubramanian, N., Lee, C. F., Wong, K. S., & Chen, C. L. (2015). The value of patient selection in demonstrating treatment effect in stroke recovery trials: lessons from the CHIMES study of MLC601 (NeuroAiD). J Evid Based Med, 8(3), 149-153.
    DOI: 10.1111/jebm.12170
  30. Venketasubramanian, N., Young, S. H., Tay, S. S., Umapathi, T., Lao, A. Y., Gan, H. H., Baroque, A. C., 2nd, Navarro, J. C., Chang, H. M., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P., Chua, C. L., Wijekoon, N., de Silva, H. A., Hiyadan, J. H., Suwanwela, N. C., Wong, K. S., Poungvarin, N., Eow, G. B., Lee, C. F., Chen, C. L., & Investigators, C.-E. S. (2015). CHInese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy. Cerebrovasc Dis, 39(5-6), 309-318.
    DOI: 10.1159/000382082
  31. Verhaaren, B. F., Debette, S., Bis, J. C., Smith, J. A., Ikram, M. K., Adams, H. H., Beecham, A. H., Rajan, K. B., Lopez, L. M., Barral, S., van Buchem, M. A., van der Grond, J., Smith, A. V., Hegenscheid, K., Aggarwal, N. T., de Andrade, M., Atkinson, E. J., Beekman, M., Beiser, A. S., Blanton, S. H., Boerwinkle, E., Brickman, A. M., Bryan, R. N., Chauhan, G., Chen, C. P., Chouraki, V., de Craen, A. J., Crivello, F., Deary, I. J., Deelen, J., De Jager, P. L., Dufouil, C., Elkind, M. S., Evans, D. A., Freudenberger, P., Gottesman, R. F., Guethnason, V., Habes, M., Heckbert, S. R., Heiss, G., Hilal, S., Hofer, E., Hofman, A., Ibrahim-Verbaas, C. A., Knopman, D. S., Lewis, C. E., Liao, J., Liewald, D. C., Luciano, M., van der Lugt, A., Martinez, O. O., Mayeux, R., Mazoyer, B., Nalls, M., Nauck, M., Niessen, W. J., Oostra, B. A., Psaty, B. M., Rice, K. M., Rotter, J. I., von Sarnowski, B., Schmidt, H., Schreiner, P. J., Schuur, M., Sidney, S. S., Sigurdsson, S., Slagboom, P. E., Stott, D. J., van Swieten, J. C., Teumer, A., Toglhofer, A. M., Traylor, M., Trompet, S., Turner, S. T., Tzourio, C., Uh, H. W., Uitterlinden, A. G., Vernooij, M. W., Wang, J. J., Wong, T. Y., Wardlaw, J. M., Windham, B. G., Wittfeld, K., Wolf, C., Wright, C. B., Yang, Q., Zhao, W., Zijdenbos, A., Jukema, J. W., Sacco, R. L., Kardia, S. L., Amouyel, P., Mosley, T. H., Longstreth, W. T., Jr., DeCarli, C. C., van Duijn, C. M., Schmidt, R., Launer, L. J., Grabe, H. J., Seshadri, S. S., Ikram, M. A., & Fornage, M. (2015). Multiethnic genomewide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet, 8(2), 398-409.
    DOI: 10.1161/CIRCGENETICS.114.000858
  32. Wong, M. Y., Chen, C. L., Ong, Y. T., Hilal, S., Ikram, M. K., Kumari, N., Yip, C. C., Venketasubramanian, N., Yap, P., Seow, D., Wong, T. Y., & Cheung, C. Y. (2015). High prevalence of undiagnosed eye diseases in individuals with dementia. J Am Geriatr Soc, 63(1), 192-194.
    DOI: 10.1111/jgs.13228
  33. Xu, X., Ang, S. L., Hilal, S., Chan, Q. L., Wong, T. Y., Venketasubramanian, N., Ikram, M. K., & Chen, C. L. (2015). Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. Int Psychogeriatr, 27(11), 1839-1847.
    DOI: 10.1017/S1041610215000976
  34. Xu, X., Chong, E., Hilal, S., Ikram, M. K., Venketasubramanian, N., & Chen, C. (2015). Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic? Diagnostics (Basel), 5(4), 475-486.
    DOI: 10.3390/diagnostics5040475
  35. Xu, X., Hilal, S., Collinson, S. L., Chong, E. J., Ikram, M. K., Venketasubramanian, N., & Chen, C. L. (2015). Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition. Stroke, 46(10), 2808-2814.
    DOI: 10.1161/STROKEAHA.115.010700

Year 2014 -

  1. Adav, S. S., Qian, J., Ang, Y. L., Kalaria, R. N., Lai, M. K., Chen, C. P., & Sze, S. K. (2014). iTRAQ quantitative clinical proteomics revealed role of Na(+)K(+)-ATPase and its correlation with deamidation in vascular dementia. J Proteome Res, 13(11), 4635-4646.
    DOI: 10.1021/pr500754j
  2. Bhuiyan, A., Cheung, C. Y., Frost, S., Lamoureux, E., Mitchell, P., Kanagasingam, Y., & Wong, T. Y. (2014). Development and reliability of retinal arteriolar central light reflex quantification system: a new approach for severity grading. Invest Ophthalmol Vis Sci, 55(12), 7975-7981.
    DOI: 10.1167/iovs.14-14125
  3. Cheung, C. Y., Ong, S., Ikram, M. K., Ong, Y. T., Chen, C. P., Venketasubramanian, N., & Wong, T. Y. (2014). Retinal vascular fractal dimension is associated with cognitive dysfunction. J Stroke Cerebrovasc Dis, 23(1), 43-50.
    DOI: 10.1016/j.jstrokecerebrovasdis.2012.09.002
  4. Cheung, C. Y., Ong, Y. T., Ikram, M. K., Chen, C., & Wong, T. Y. (2014). Retinal microvasculature in Alzheimer's disease. J Alzheimers Dis, 42 Suppl 4, S339-352.
    DOI: 10.3233/JAD-141596
  5. Cheung, C. Y., Ong, Y. T., Ikram, M. K., Ong, S. Y., Li, X., Hilal, S., Catindig, J. A., Venketasubramanian, N., Yap, P., Seow, D., Chen, C. P., & Wong, T. Y. (2014). Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimers Dement, 10(2), 135-142.
    DOI: 10.1016/j.jalz.2013.06.009
  6. Chopdar, A., & Aung, T. (2014). Multimodal retinal imaging: JP Medical Ltd.
    ISBN-13: 978-1907816604
  7. Datta, A., Qian, J., Chong, R., Kalaria, R. N., Francis, P., Lai, M. K., Chen, C. P., & Sze, S. K. (2014). Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia. J Proteomics, 99, 54-67.
    DOI: 10.1016/j.jprot.2014.01.011
  8. Dong, Y., Cheng, T. S., Tsou, K. Y., Chan, Q. L., & Chen, C. L. (2014). Feasibility and acceptability of the informant AD8 for cognitive screening in primary healthcare: a pilot study. ScientificWorldJournal, 2014, 302834.
    DOI: 10.1155/2014/302834
  9. Dong, Y., Slavin, M. J., Chan, B. P., Venketasubramanian, N., Sharma, V. K., Collinson, S. L., Sachdev, P. S., & Chen, C. L. (2014). Improving screening for vascular cognitive impairment at three to six months after mild ischemic stroke and transient ischemic attack. Int Psychogeriatr, 26(5), 787- 793.
    DOI: 10.1017/S1041610213002457
  10. Goh, D. A., Dong, Y., Lee, W. Y., Koay, W. I., Tay, S. Z., Soon, D., Chen, C., Brittain, C. F., Lowe, S. L., & Wong, B. S. (2014). A pilot study to examine the correlation between cognition and blood biomarkers in a Singapore Chinese male cohort with type 2 diabetes mellitus. PLoS One, 9(5), e96874.
    DOI: 10.1371/journal.pone.0096874
  11. Hilal, S., Ong, Y. T., Cheung, C. Y., Tan, C. S., Venketasubramanian, N., Niessen, W. J., Vrooman, H., Anuar, A. R., Chew, M., Chen, C., Wong, T. Y., & Ikram, M. K. (2014). Microvascular network alterations in retina of subjects with cerebral small vessel disease. Neurosci Lett, 577, 95-100.
    DOI: 10.1016/j.neulet.2014.06.024
  12. Hilal, S., Saini, M., Tan, C. S., Catindig, J. A., Dong, Y. H., Leon, L. B., Niessen, W. J., Vrooman, H., Wong, T. Y., Chen, C., Venketasubramanian, N., & Ikram, M. K. (2014). Ankle-brachial index, cognitive impairment and cerebrovascular disease in a Chinese population. Neuroepidemiology, 42(2), 131-138.
    DOI: 10.1159/000357372
  13. Hilal, S., Saini, M., Tan, C. S., Catindig, J. A., Koay, W. I., Niessen, W. J., Vrooman, H. A., Wong, T. Y., Chen, C., Ikram, M. K., & Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer Dis Assoc Disord, 28(2), 106-112.
    DOI: 10.1097/WAD.0000000000000015
  14. Hilal, S., Saini, M., Tan, C. S., Catindig, J. A., Koay, W. I., Niessen, W. J., Vrooman, H. A., Wong, T. Y., Chen, C., Ikram, M. K., & Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer Dis Assoc Disord, 28(2), 106-112.
    DOI: 10.1097/WAD.0000000000000015
  15. Jickling, G. C., & Chen, C. (2014). Rating total cerebral small-vessel disease: does it add up? Neurology, 83(14), 1224-1225.
    DOI: 10.1212/WNL.0000000000000843
  16. Lam, S. M., Wang, Y., Duan, X., Wenk, M. R., Kalaria, R. N., Chen, C. P., Lai, M. K., & Shui, G. (2014). Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiol Aging, 35(10), 2369-2381.
    DOI: 10.1016/j.neurobiolaging.2014.02.025
  17. Lau, A. Y., Zhao, Y., Chen, C., Leung, T. W., Fu, J., Huang, Y., Suwanwela, N. C., Han, Z., Tan, K. S., Ratanakorn, D., Markus, H. S., Wong, K. S., & Investigators, C. S. (2014). Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study. Int J Stroke, 9 Suppl A100, 127-132.
    DOI: 10.1111/ijs.12003
  18. Miura, Y., Miyaji, K., Chai, Y. L., Chen, C. L., Lai, M. K., & Yuki, N. (2014). Autoantibodies to GM1 and GQ1balpha are not biological markers of Alzheimer's disease. J Alzheimers Dis, 42(4), 1165-1169.
    DOI: 10.3233/JAD-140474
  19. Mohamed, N. E., Howlett, D. R., Ma, L., Francis, P. T., Aarsland, D., Ballard, C. G., McKeith, I. G., Chen, C. P., & Lai, M. K. (2014). Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias. J Neural Transm (Vienna), 121(1), 71-78.
    DOI: 10.1007/s00702-013-1067-0
  20. Navarro, J. C., Gan, H. H., Lao, A. Y., Baroque, A. C., 2nd, Hiyadan, J. H., Chua, C. L., San Jose, M. C., Advincula, J. M., Lee, C. F., Bousser, M. G., Chen, C. L., & Investigators, C. S. (2014). Baseline characteristics and treatment response of patients from the Philippines in the CHIMES study. Int J Stroke, 9 Suppl A100, 102-105.
    DOI: 10.1111/ijs.12324
  21. Ong, Y.-L., Ong, Y.-T., Ikram, M. K., Chen, C. L. H., & Wong, T. Y. (2014). Potential applications of spectral-domain optical coherence tomography (SD-OCT) in the study of Alzheimer's disease. Proceedings of Singapore Healthcare, 23(1), 74-83.
    DOI: 10.1177/201010581402300112
  22. Ong, Y. T., Hilal, S., Cheung, C. Y., Xu, X., Chen, C., Venketasubramanian, N., Wong, T. Y., & Ikram, M. K. (2014). Retinal vascular fractals and cognitive impairment. Dement Geriatr Cogn Dis Extra, 4(2), 305-313.
    DOI: 10.1159/000363286
  23. Sachdev, P., Kalaria, R., O'Brien, J., Skoog, I., Alladi, S., Black, S. E., Blacker, D., Blazer, D. G., Chen, C., Chui, H., Ganguli, M., Jellinger, K., Jeste, D. V., Pasquier, F., Paulsen, J., Prins, N., Rockwood, K., Roman, G., Scheltens, P., Internationlal Society for Vascular, B., & Cognitive, D. (2014). Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord, 28(3), 206-218.
    DOI: 10.1097/WAD.0000000000000034
  24. San Tham, L., Zhao, C. M. F., Natanegara, F., Lowe, S., Chen, C., Lim, C. N., Linnebjerg, H., & Willis, B. A. (2014). Modeling and simulations to confirm a controlled hypoglycemic stress test in healthy subjects is not associated with clinically significant QT prolongations. International journal of clinical pharmacology and therapeutics, 52(9), 717-725.
    DOI: 10.5414/CP202012
  25. Shen, J. H., Shen, Q., Yu, H., Lai, J. S., Beaumont, J. L., Zhang, Z., Wang, H., Kim, S. Y., Chen, C., Kwok, T., Wang, S. J., Lee, D. Y., Harrison, J., & Cummings, J. (2014). Validation of an Alzheimer's disease assessment battery in Asian participants with mild to moderate Alzheimer's disease. Am J Neurodegener Dis, 3(3), 158-169.
    PMCID: PMC4299719
  26. Tan, M. G., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramirez, M. J., Chen, C. P., Wong, P. T., & Lai, M. K. (2014). Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Abeta burden. Neurochem Int, 64, 29-36.
    DOI: 10.1016/j.neuint.2013.10.013
  27. Thomas, G. N., Ong, S. Y., Tham, Y. C., Hsu, W., Lee, M. L., Lau, Q. P., Tay, W., Alessi-Calandro, J., Hodgson, L., Kawasaki, R., Wong, T. Y., & Cheung, C. Y. (2014). Measurement of macular fractal dimension using a computer-assisted program. Invest Ophthalmol Vis Sci, 55(4), 2237-2243.
    DOI: 10.1167/iovs.13-13315
  28. Thong, J. Y., Du, J., Ratnarajah, N., Dong, Y., Soon, H. W., Saini, M., Tan, M. Z., Ta, A. T., Chen, C., & Qiu, A. (2014). Abnormalities of cortical thickness, subcortical shapes, and white matter integrity in subcortical vascular cognitive impairment. Hum Brain Mapp, 35(5), 2320-2332.
    DOI: 10.1002/hbm.22330
  29. Ward, A. B., Chen, C., Norrving, B., Gillard, P., Walker, M. F., Blackburn, S., Holloway, L., Brainin, M., Philp, I., & Global Stroke Community Advisory, P. (2014). Evaluation of the Post Stroke Checklist: a pilot study in the United Kingdom and Singapore. Int J Stroke, 9 Suppl A100, 76-84.
    DOI: 10.1111/ijs.12291
  30. Yip, W., Siantar, R., Perera, S. A., Milastuti, N., Ho, K. K., Tan, B., Wong, T. Y., & Cheung, C. Y. (2014). Reliability and determinants of retinal vessel oximetry measurements in healthy eyes. Invest Ophthalmol Vis Sci, 55(11), 7104-7110
    DOI: 10.1167/iovs.13-13854

Year 2013 -

  1. Chen, C., Leys, D., & Esquenazi, A. (2013). The interaction between neuropsychological and motor deficits in patients after stroke. Neurology, 80(3 Suppl 2), S27-34.
    DOI: 10.1212/WNL.0b013e3182762569
  2. Chen, C. L., Ikram, K., Anqi, Q., Yin, W. T., Chen, A., Venketasubramanian, N., & Investigators, N. (2013). The NeuroAiD II (MLC901) in vascular cognitive impairment study (NEURITES). Cerebrovasc Dis, 35 Suppl 1, 23-29.
    DOI: 10.1161/STROKEAHA.113.003226
  3. Chen, C. L., Venketasubramanian, N., Lee, C. F., Wong, K. S., Bousser, M. G., & Investigators, C. S. (2013). Effects of MLC601 on early vascular events in patients after stroke: the CHIMES study. Stroke, 44(12), 3580-3583.
    DOI: 10.1161/STROKEAHA.113.003226
  4. Chen, C. L., Young, S. H., Gan, H. H., Singh, R., Lao, A. Y., Baroque, A. C., 2nd, Chang, H. M., Hiyadan, J. H., Chua, C. L., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P., de Silva, H. A., Towanabut, S., Suwanwela, N. C., Poungvarin, N., Chankrachang, S., Wong, K. S., Eow, G. B., Navarro, J. C., Venketasubramanian, N., Lee, C. F., Bousser, M. G., & Investigators, C. S. (2013). Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study. Stroke, 44(8), 2093-2100.
    DOI: 10.1161/STROKEAHA.113.002055
  5. Cheung, C. Y., Tay, W. T., Ikram, M. K., Ong, Y. T., De Silva, D. A., Chow, K. Y., & Wong, T. Y. (2013). Retinal microvascular changes and risk of stroke: the Singapore Malay Eye Study. Stroke, 44(9), 2402- 2408
    DOI: 10.1161/STROKEAHA.113.001738
  6. De Silva, D. A., Omar, E., Manzano, J. J., Christensen, S., Allen, J. C., Jr., Bath, P. M., Chang, H. M., Wong, M. C., & Chen, C. P. (2013). Comparison of small volume infarcts of lacunar and non-lacunar etiologies. Int J Stroke, 8(5), E24-25.
    DOI: 10.1111/ijs.12120
  7. Do, D. V., Ueda, J., Messerschmidt, D. M., Lorthongpanich, C., Zhou, Y., Feng, B., Guo, G., Lin, P. J., Hossain, M. Z., Zhang, W., Moh, A., Wu, Q., Robson, P., Ng, H. H., Poellinger, L., Knowles, B. B., Solter, D., & Fu, X. Y. (2013). A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev, 27(12), 1378-1390.
    DOI: 10.1101/gad.221176.113
  8. Dong, Y., Gan, D. Z., Tay, S. Z., Koay, W. I., Collinson, S. L., Hilal, S., Venketasubramanian, N., & Chen, C. (2013). Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia. J Neurol Sci, 333(1-2), 5-8.
    DOI: 10.1016/j.jns.2013.05.011
  9. Ikram, M. K., Ong, Y. T., Cheung, C. Y., & Wong, T. Y. (2013). Retinal vascular caliber measurements: clinical significance, current knowledge and future perspectives. Ophthalmologica, 229(3), 125-136.
    DOI: 10.1159/000342158
  10. Dong, Y., Pang, W. S., Lim, L. B., Yang, Y. H., Morris, J. C., Hilal, S., Venketasubramanian, N., & Chen, C. L. (2013). The informant AD8 is superior to participant AD8 in detecting cognitive impairment in a memory clinic setting. J Alzheimers Dis, 35(1), 159-168.
    DOI: 10.3233/JAD-122026
  11. Dong, Y., Slavin, M. J., Chan, B. P., Venketasubramanian, N., Sharma, V. K., Crawford, J. D., Collinson, S. L., Sachdev, P., & Chen, C. L. (2013). Cognitive screening improves the predictive value of stroke severity scores for functional outcome 3-6 months after mild stroke and transient ischaemic attack: an observational study. BMJ Open, 3(9), e003105.
    DOI: 10.1136/bmjopen-2013-003105
  12. Dong, Y., Thompson, C. L., Tan, S. H. J., Lim, L. B. S., Pang, W., & Chen, C. L.-H. (2013). Test-retest reliability, convergent validity and practice effects of the RBANS in a memory clinic setting: a pilot study. Open Journal of Medical Psychology, 2(04), 11.
    DOI: 10.4236/ojmp.2013.24B003
  13. Dong, Y., Yean Lee, W., Hilal, S., Saini, M., Wong, T. Y., Chen, C. L., Venketasubramanian, N., & Ikram, M. K. (2013). Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study. Int Psychogeriatr, 25(11), 1831-1838.
    DOI: 10.1017/S1041610213001129
  14. Gommans, J., Yi, Q., Eikelboom, J. W., Hankey, G. J., Chen, C., Rodgers, H., & group, V. t. s. (2013). The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial. BMC Geriatr, 13, 88.
    DOI: 10.1186/1471-2318-13-88
  15. Hankey, G. J., Ford, A. H., Yi, Q., Eikelboom, J. W., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., Almeida, O. P., van Bockxmeer, F. M., & Group, V. T. S. (2013). Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis. Stroke, 44(8), 2232-2239.
    DOI: 10.1161/STROKEAHA.113.001886
  16. Hilal, S., Ikram, M. K., Saini, M., Tan, C. S., Catindig, J. A., Dong, Y. H., Lim, L. B., Ting, E. Y., Koo, E. H., Cheung, C. Y., Qiu, A., Wong, T. Y., Chen, C. L., & Venketasubramanian, N. (2013). Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry, 84(6), 686-692.
    DOI: 10.1136/jnnp-2012-304080
  17. Ikram, M. K., Cheung, C. Y., Lorenzi, M., Klein, R., Jones, T. L., Wong, T. Y., & Group, N. J. W. o. R. B. f. D. (2013). Retinal vascular caliber as a biomarker for diabetes microvascular complications. Diabetes Care, 36(3), 750-759.
    DOI: 10.2337/dc12-1554
  18. Li, X., Wong, W. L., Cheung, C. Y., Cheng, C. Y., Ikram, M. K., Li, J., Chia, K. S., & Wong, T. Y. (2013). Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians. Invest Ophthalmol Vis Sci, 54(5), 3650-3656.
    DOI: 10.1167/iovs.12-11126
  19. Lim, M., Sasongko, M. B., Ikram, M. K., Lamoureux, E., Wang, J. J., Wong, T. Y., & Cheung, C. Y. (2013). Systemic associations of dynamic retinal vessel analysis: a review of current literature. Microcirculation, 20(3), 257-268.
    DOI: 10.1111/micc.12026
  20. Lim, Y. A., Murray, L. A., Lai, M. K., & Chen, C. (2013). NeuroAiD(R) (MLC601) and amyloid precursor protein processing. Cerebrovasc Dis, 35 Suppl 1, 30-37.
    DOI: 10.1159/000346236
  21. Mishra, N. K., Chan, B. P., Teoh, H. L., Meng, C. H., Lees, K. R., Chen, C., Sharma, V. K., & Collaboration, V. (2013). Postthrombolysis outcomes in acute ischemic stroke patients of Asian raceethnicity. Int J Stroke, 8 Suppl A100, 95-99.
    DOI: 10.1111/ijs.12012
  22. Nagaendran, K., Chen, L. H., Chong, M. S., Chua, E. V., Goh, C. K., Kua, J., Lee, T., Shiong, L. W., Marziyana, A. R., Ng, C. C., Ng, L. L., Seow, D., Sitoh, Y. Y., Yap, L. K., Yeo, D., & Yeo, Y. (2013). Ministry of health clinical practice guidelines: dementia. Singapore Med J, 54(5), 293-298; quiz 299.
    DOI: 10.11622/smedj.2013112
  23. Navarro, J. C., Chen, C. L., Lagamayo, P. D., Geslani, M. B., Eow, G. B., Poungvarin, N., de Silva, A., Wong, L. K., Venketasubramanian, N., & Investigators, C. (2013). CHIMES-I: sub-group analyzes of the effects of NeuroAiD according to baseline brain imaging characteristics among patients randomized in the CHIMES study. Int J Stroke, 8(6), 491-494.
    DOI: 10.1111/ijs.12044
  24. Ong, S. Y., Ikram, M. K., Haaland, B. A., Cheng, C. Y., Saw, S. M., Wong, T. Y., & Cheung, C. Y. (2013). Myopia and cognitive dysfunction: the singapore malay eye study. Invest Ophthalmol Vis Sci, 54(1), 799-803.
    DOI: 10.1167/iovs.12-10460
  25. Ong, Y. T., De Silva, D. A., Cheung, C. Y., Chang, H. M., Chen, C. P., Wong, M. C., Wong, T. Y., & Ikram, M. K. (2013). Microvascular structure and network in the retina of patients with ischemic stroke. Stroke, 44(8), 2121-2127.
    DOI: 10.1161/STROKEAHA.113.001741
  26. Shalev, I., Moffitt, T. E., Wong, T. Y., Meier, M. H., Houts, R. M., Ding, J., Cheung, C. Y., Ikram, M. K., Caspi, A., & Poulton, R. (2013). Retinal vessel caliber and lifelong neuropsychological functioning: retinal imaging as an investigative tool for cognitive epidemiology. Psychol Sci, 24(7), 1198-1207.
    DOI: 10.1177/0956797612470959
  27. Siddiqui, F. J., Venketasubramanian, N., Chan, E. S., & Chen, C. (2013). Efficacy and safety of MLC601 (NeuroAiD(R)), a traditional Chinese medicine, in poststroke recovery: a systematic review. Cerebrovasc Dis, 35 Suppl 1, 8-17.
    DOI: 10.1159/000346231
  28. Tham, Y. C., Cheng, C. Y., Zheng, Y., Aung, T., Wong, T. Y., & Cheung, C. Y. (2013). Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes. Invest Ophthalmol Vis Sci, 54(12), 7309-7316.
    DOI: 10.1167/iovs.13-12796
  29. Thong, J. Y., Hilal, S., Wang, Y., Soon, H. W., Dong, Y., Collinson, S. L., Anh, T. T., Ikram, M. K., Wong, T. Y., Venketasubramanian, N., Chen, C., & Qiu, A. (2013). Association of silent lacunar infarct with brain atrophy and cognitive impairment. J Neurol Neurosurg Psychiatry, 84(11), 1219-1225.
    DOI: 10.1136/jnnp-2013-305310
  30. Venketasubramanian, N., Young, S., Tay, S. S., Chang, H. M., Umapathi, T., Chan, B., de Silva, A., Wong, L., Navarro, J., Zhao, Y. D., Tan, S. B., & Chen, C. (2013). Chinese medicine NeuroAiD efficacy stroke recovery-extension study (CHIMES-E study): an observational multicenter study to investigate the longer-term efficacy of NeuroAiD in stroke recovery. Cerebrovasc Dis, 35 Suppl 1, 18-22.
    DOI: 10.1159/000346233
  31. Wang, X., Lin, W. H., Zhao, Y. D., Chen, X. Y., Leung, T. W., Chen, C., Fu, J., Markus, H., Hao, Q., Wong, K. S., & Investigators, C. S. (2013). The effectiveness of dual antiplatelet treatment in acute ischemic stroke patients with intracranial arterial stenosis: a subgroup analysis of CLAIR study. Int J Stroke, 8(8), 663-668.
    DOI: 10.1111/j.1747-4949.2012.00828.x
  32. Wardlaw, J. M., Smith, E. E., Biessels, G. J., Cordonnier, C., Fazekas, F., Frayne, R., Lindley, R. I., O'Brien, J. T., Barkhof, F., Benavente, O. R., Black, S. E., Brayne, C., Breteler, M., Chabriat, H., Decarli, C., de Leeuw, F. E., Doubal, F., Duering, M., Fox, N. C., Greenberg, S., Hachinski, V., Kilimann, I., Mok, V., Oostenbrugge, R., Pantoni, L., Speck, O., Stephan, B. C., Teipel, S., Viswanathan, A., Werring, D., Chen, C., Smith, C., van Buchem, M., Norrving, B., Gorelick, P. B., Dichgans, M., & nEuroimaging, S. T. f. R. V. c. o. (2013). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol, 12(8), 822- 838.
    DOI: 10.1016/S1474-4422(13)70124-8

Year 2012 -

  1. Catindig, J. A., Venketasubramanian, N., Ikram, M. K., & Chen, C. (2012). Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors. J Neurol Sci, 321(1-2), 11-16.
    DOI: 10.1016/j.jns.2012.07.023
  2. Cavalieri, M., Schmidt, R., Chen, C., Mok, V., de Freitas, G. R., Song, S., Yi, Q., Ropele, S., Grazer, A., Homayoon, N., Enzinger, C., Loh, K., Wong, K. S., Wong, A., Xiong, Y., Chang, H. M., Wong, M. C., Fazekas, F., Eikelboom, J. W., Hankey, G. J., & Group, V. T. S. (2012). B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy. Stroke, 43(12), 3266-3270.
    DOI: 10.1161/STROKEAHA.112.665703
  3. Cheung, C. Y., Ikram, M. K., Sabanayagam, C., & Wong, T. Y. (2012). Retinal microvasculature as a model to study the manifestations of hypertension. Hypertension, 60(5), 1094-1103.
    DOI: 10.1161/HYPERTENSIONAHA.111.189142
  4. De Silva, D. A., Woon, F. P., Manzano, J. J., Liu, E. Y., Chang, H. M., Chen, C., Wang, J. J., Mitchell, P., Kingwell, B. A., Cameron, J. D., Lindley, R. I., Wong, T. Y., Wong, M. C., & behalf of the MultiCentre Retinal Stroke Study Collaborative, G. (2012). The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. J Hum Hypertens, 26(12), 716- 722.
    DOI: 10.1038/jhh.2011.88
  5. Dong, Y., Lee, W. Y., Basri, N. A., Collinson, S. L., Merchant, R. A., Venketasubramanian, N., & Chen, C. L. (2012). The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. Int Psychogeriatr, 24(11), 1749-1755.
    DOI: 10.1017/S1041610212001068
  6. Dong, Y., Teoh, H. L., Chan, B. P., Ning, C., Yeo, T. T., Sinha, A. K., Venketasubramanian, N., Slavin, M. J., Sachdev, P., Collinson, S. L., Chen, C., & Sharma, V. K. (2012). Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study. J Neurol Sci, 322(1-2), 112-116.
    DOI: 10.1016/j.jns.2012.07.034
  7. Dong, Y., Venketasubramanian, N., Chan, B. P., Sharma, V. K., Slavin, M. J., Collinson, S. L., Sachdev, P., Chan, Y. H., & Chen, C. L. (2012). Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke. J Neurol Neurosurg Psychiatry, 83(6), 580-585.
    DOI: 10.1136/jnnp-2011-302070
  8. Geeganage, C. M., Diener, H. C., Algra, A., Chen, C., Topol, E. J., Dengler, R., Markus, H. S., Bath, M. W., Bath, P. M., & Acute Antiplatelet Stroke Trialists, C. (2012). Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and metaanalysis of randomized controlled trials. Stroke, 43(4), 1058-1066.
    DOI: 10.1161/STROKEAHA.111.637686
  9. Ikram, M. K., Cheung, C. Y., Wong, T. Y., & Chen, C. P. (2012). Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry, 83(9), 917-922.
    DOI: 10.1136/jnnp-2011-301628
  10. Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., & Group, V. I. T. P. S. T. S. (2012). Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial. Stroke, 43(6), 1572-1577.
    DOI: 10.1161/STROKEAHA.111.641613
  11. Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., & group, V. t. s. (2012). Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol, 11(6), 512-520.
    DOI: 10.1016/S1474-4422(12)70091-1
  12. Manzano, J. J., De Silva, D. A., Pascual, J. L., Chang, H. M., Wong, M. C., & Chen, C. P. (2012). Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. Atherosclerosis, 223(1), 219-222.
    DOI: 10.1016/j.atherosclerosis.2012.04.009
  13. Ong, S. Y., Cheung, C. Y., Li, X., Lamoureux, E. L., Ikram, M. K., Ding, J., Cheng, C. Y., Haaland, B. A., Saw, S. M., Venketasubramanian, N., Chen, C. P., & Wong, T. Y. (2012). Visual impairment, agerelated eye diseases, and cognitive function: the Singapore Malay Eye study. Arch Ophthalmol, 130(7), 895-900.
    DOI: 10.1001/archophthalmol.2012.152
  14. Saini, M., Ikram, K., Hilal, S., Qiu, A., Venketasubramanian, N., & Chen, C. (2012). Silent stroke: not listened to rather than silent. Stroke, 43(11), 3102-3104.
    DOI: 10.1161/STROKEAHA.112.666461
  15. Sheng, Y., Lee, J. H., Medhurst, A. D., Wilcock, G. K., Esiri, M., Wong, P. T., Chen, C. P., & Lai, M. K. (2012). Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. J Neurol Sci, 315(1-2), 110-114.
    DOI: 10.1016/j.jns.2011.11.013
  16. Wang, Q., Chen, C., Chen, X. Y., Han, J. H., Soo, Y., Leung, T. W., Mok, V., & Wong, K. S. (2012). Low-molecular-weight heparin and early neurologic deterioration in acute stroke caused by large artery occlusive disease. Arch Neurol, 69(11), 1454-1460.
    DOI: 10.1001/archneurol.2012.1633
  17. Wang, Q. S., Chen, C., Chen, X. Y., Han, J. H., Soo, Y., Leung, T. W., Mok, V., & Wong, K. S. (2012). Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study. Stroke, 43(2), 346-349.
    DOI: 10.1161/STROKEAHA.111.628347
  18. Wang, Y., Catindig, J. A., Hilal, S., Soon, H. W., Ting, E., Wong, T. Y., Venketasubramanian, N., Chen, C., & Qiu, A. (2012). Multi-stage segmentation of white matter hyperintensity, cortical and lacunar infarcts. Neuroimage, 60(4), 2379-2388.
    DOI: 10.1016/j.neuroimage.2012.02.034

Year 2011 -

  1. De Silva, D. A., Manzano, J. J., Liu, E. Y., Woon, F. P., Wong, W. X., Chang, H. M., Chen, C., Lindley, R. I., Wang, J. J., Mitchell, P., Wong, T. Y., Wong, M. C., & Multi-Centre Retinal Stroke Study, G. (2011). Retinal microvascular changes and subsequent vascular events after ischemic stroke. Neurology, 77(9), 896-903.
    DOI: 10.1212/WNL.0b013e31822c623b
  2. De Silva, D. A., Manzano, J. J., Woon, F. P., Liu, E. Y., Lee, M. P., Gan, H. Y., Chen, C. P., Chang, H. M., Mitchell, P., Wang, J. J., Lindley, R. I., Wong, T. Y., & Wong, M. C. (2011). Associations of retinal microvascular signs and intracranial large artery disease. Stroke, 42(3), 812-814.
    DOI: 10.1212/WNL.0b013e31822c623b
  3. Goh, C. W., Aw, C. C., Lee, J. H., Chen, C. P., & Browne, E. R. (2011). Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug Metab Dispos, 39(3), 402-411.
    DOI: 10.1212/WNL.0b013e31822c623b
  4. Lai, M. K., Tsang, S. W., Esiri, M. M., Francis, P. T., Wong, P. T., & Chen, C. P. (2011). Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease. Psychopharmacology (Berl), 213(2-3), 431-439.
    DOI: 10.1212/WNL.0b013e31822c623b
  5. Low, H. Q., Chen, C. P., Kasiman, K., Thalamuthu, A., Ng, S. S., Foo, J. N., Chang, H. M., Wong, M. C., Tai, E. S., & Liu, J. (2011). A comprehensive association analysis of homocysteine metabolic pathway genes in Singaporean Chinese with ischemic stroke. PLoS One, 6(9), e24757.
    DOI: 10.1212/WNL.0b013e31822c623b
  6. Mohamed, N. E., Zhao, Y., Lee, J. H., Tan, M. G., Esiri, M. M., Wilcock, G. K., Smith, A. D., Wong, P. T., Chen, C. P., & Lai, M. K. (2011). Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. Neurochem Int, 58(7), 820-825.
    DOI: 10.1212/WNL.0b013e31822c623b
  7. Narasimhalu, K., Ang, S., De Silva, D. A., Wong, M. C., Chang, H. M., Chia, K. S., Auchus, A. P., & Chen, C. P. (2011). The prognostic effects of poststroke cognitive impairment no dementia and domain-specific cognitive impairments in nondisabled ischemic stroke patients. Stroke, 42(4), 883- 888.
    DOI: 10.1212/WNL.0b013e31822c623b
  8. Venketasubramanian, N., Chan, B. P., Chang, H. M., Chua, H. C., Gan, R. N., Hui, F., Lee, W., Ng, I., Sharma, V. K., Singh, R., Teoh, H. L., Wang, E., & Chen, C. L. (2011). Brain attack: needing resuscitation. Singapore Med J, 52(8), 620-630.
    PMID: 21879224
  9. Zhao, Y., Ho, P., Yih, Y., Chen, C., Lee, W. L., & Tan, E. K. (2011). LRRK2 variant associated with Alzheimer's disease. Neurobiol Aging, 32(11), 1990-1993.
    DOI: 10.1016/j.neurobiolaging.2009.11.019
  10. Venketasubramanian, N., Pwee, K. H., Chen, C. P., Singapore Ministry of Health Clinical Practice Guidelines Workgroup on, S., & Transient Ischaemic, A. (2011). Singapore ministry of health clinical practice guidelines on stroke and transient ischemic attacks. Int J Stroke, 6(3), 251-258.
    DOI: 10.1111/j.1747-4949.2011.00602.x

Year 2010 -

  1. Aisa, B., Gil-Bea, F. J., Solas, M., Garcia-Alloza, M., Chen, C. P., Lai, M. K., Francis, P. T., & Ramirez, M. J. (2010). Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. J Alzheimers Dis, 20(2), 659-668.
    DOI: 10.3233/JAD-2010-1398
  2. Chen, C. L., Willis, B. A., Mooney, L., Ong, G. K., Lim, C. N., Lowe, S. L., Tauscher-Wisniewski, S., Cutler, G. B., Jr., & Wiss, S. D. (2010). Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation. Br J Clin Pharmacol, 70(6), 886- 894.
    DOI: 10.1111/j.1365-2125.2010.03781.x
  3. Dong, Y., Sharma, V. K., Chan, B. P., Venketasubramanian, N., Teoh, H. L., Seet, R. C., Tanicala, S., Chan, Y. H., & Chen, C. (2010). The Montreal Cognitive Assessment (MoCA) is superior to the MiniMental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. J Neurol Sci, 299(1-2), 15-18.
    DOI: 10.1016/j.jns.2010.08.051
  4. Group, V. T. S. (2010). B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebocontrolled trial. Lancet Neurol, 9(9), 855-865.
    DOI: 10.1016/s1474-4422(10)70187-3
  5. Hankey, G. J., Wong, K. S., Chankrachang, S., Chen, C., Crimmins, D., Frayne, J., Kim, J. S., Li, Y., Liou, C. W., Merican, J. S., Misbach, J., Navarro, J., Shinohara, Y., Wang, Y., Yoon, B. W., Working Group on, S., & Lipids Management in Asia Consensus, P. (2010). Management of cholesterol to reduce the burden of stroke in Asia: consensus statement. Int J Stroke, 5(3), 209-216.
    DOI: 10.1111/j.1747-4949.2010.00429.x
  6. Hao, Q., Chang, H. M., Wong, M. C., Wong, K. S., & Chen, C. (2010). Frequency of microemboli signal in stroke patients treated with low molecular weight heparin or aspirin. J Neuroimaging, 20(2), 118- 121.
    DOI: 10.1111/j.1552-6569.2008.00339.x
  7. Lai, M. K., Chen, C. P., Hope, T., & Esiri, M. M. (2010). Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia. Neuroreport, 21(17), 1111-1115.
    DOI: 10.1097/WNR.0b013e3283407204
  8. Lee, J. H., Agacinski, G., Williams, J. H., Wilcock, G. K., Esiri, M. M., Francis, P. T., Wong, P. T., Chen, C. P., & Lai, M. K. (2010). Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. Neurochem Int, 57(8), 985-989.
    DOI: 10.1016/j.neuint.2010.10.010
  9. Narasimhalu, K., Effendy, S., Sim, C. H., Lee, J. M., Chen, I., Hia, S. B., Xue, H. L., Corrales, M. P., Chang, H. M., Wong, M. C., Chen, C. P., & Tan, E. K. (2010). A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease. Acta Neurol Scand, 121(4), 217-224.
    DOI: 10.1111/j.1600-0404.2009.01263.x
  10. Seet, R. C., Kasiman, K., Gruber, J., Tang, S. Y., Wong, M. C., Chang, H. M., Chan, Y. H., Halliwell, B., & Chen, C. P. (2010). Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. Atherosclerosis, 209(1), 215-219.
    DOI: 10.1016/j.atherosclerosis.2009.08.012
  11. Tan, M. G., Chua, W. T., Esiri, M. M., Smith, A. D., Vinters, H. V., & Lai, M. K. (2010). Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. J Neurosci Res, 88(6), 1157-1169.
    DOI: 10.1002/jnr.22290
  12. Tsang, S. W., Keene, J., Hope, T., Spence, I., Francis, P. T., Wong, P. T., Chen, C. P., & Lai, M. K. (2010). A serotoninergic basis for hyperphagic eating changes in Alzheimer's disease. J Neurol Sci, 288(1-2), 151-155.
    DOI: 10.1016/j.jns.2009.08.066
  13. Venketasubramanian, N., Sahadevan, S., Kua, E. H., Chen, C. P., & Ng, T. P. (2010). Interethnic differences in dementia epidemiology: global and Asia-Pacific perspectives. Dement Geriatr Cogn Disord, 30(6), 492-498.
    DOI: 10.1159/000321675
  14. Wong, K. S., Chen, C., Fu, J., Chang, H. M., Suwanwela, N. C., Huang, Y. N., Han, Z., Tan, K. S., Ratanakorn, D., Chollate, P., Zhao, Y., Koh, A., Hao, Q., Markus, H. S., & investigators, C. s. (2010). Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blindedendpoint trial. Lancet Neurol, 9(5), 489-497.
    DOI: 10.1016/S1474-4422(10)70060-0
  15. Young, S. H., Zhao, Y., Koh, A., Singh, R., Chan, B. P., Chang, H. M., Venketasubramanian, N., Chen, C., & Investigators, C. (2010). Safety profile of MLC601 (Neuroaid) in acute ischemic stroke patients: A Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study. Cerebrovasc Dis, 30(1), 1-6.
    DOI: 10.1159/000313398

Year 2009 -

  1. Chen, C., Venketasubramanian, N., Gan, R. N., Lambert, C., Picard, D., Chan, B. P., Chan, E., Bousser, M. G., & Xuemin, S. (2009). Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery. Stroke, 40(3), 859-863.
    DOI: 10.1161/STROKEAHA.108.531616
  2. De Silva, D. A., Ancalan, M., Doshi, K., Chang, H. M., Wong, M. C., & Chen, C. (2009). Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. Eur J Neurol, 16(5), 643-645.
    DOI: 10.1111/j.1468-1331.2009.02551.x
  3. De Silva, D. A., Liew, G., Wong, M. C., Chang, H. M., Chen, C., Wang, J. J., Baker, M. L., Hand, P. J., Rochtchina, E., Liu, E. Y., Mitchell, P., Lindley, R. I., & Wong, T. Y. (2009). Retinal vascular caliber and extracranial carotid disease in patients with acute ischemic stroke: the Multi-Centre Retinal Stroke (MCRS) study. Stroke, 40(12), 3695-3699.
    DOI: 10.1161/STROKEAHA.109.559435
  4. De Silva, D. A., Woon, F. P., Chen, C., Chang, H. M., & Wong, M. C. (2009). Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity? J Neurol Sci, 276(1-2), 126-129.
    DOI: 10.1016/j.jns.2008.09.015
  5. De Silva, D. A., Woon, F. P., Chen, C. L., Chang, H. M., & Wong, M. C. (2009). Ethnic South Asian ischaemic stroke patients have a higher prevalence of a family history of vascular disease compared to age, gender and diabetes-matched ethnic Chinese subjects. J Neurol Sci, 285(1-2), 118-120.
    DOI: 10.1016/j.jns.2009.06.013
  6. De Silva, D. A., Woon, F. P., Gan, H. Y., Chen, C. P., Chang, H. M., Koh, T. H., Kingwell, B. A., Cameron, J. D., & Wong, M. C. (2009). Arterial stiffness is associated with intracranial large artery disease among ethnic Chinese and South Asian ischemic stroke patients. J Hypertens, 27(7), 1453- 1458.
    DOI: 10.1097/HJH.0b013e32832a8dc5
  7. De Silva, D. A., Woon, F. P., Lee, M. P., Chen, C. L., Chang, H. M., & Wong, M. C. (2009). Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke. J Stroke Cerebrovasc Dis, 18(6), 424-427.
    DOI: 10.1016/j.jstrokecerebrovasdis.2009.01.010
  8. Gruber, J., Tang, S. Y., Jenner, A. M., Mudway, I., Blomberg, A., Behndig, A., Kasiman, K., Lee, C. Y., Seet, R. C., Zhang, W., Chen, C., Kelly, F. J., & Halliwell, B. (2009). Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. Antioxid Redox Signal, 11(8), 1767-1776.
    DOI: 10.1089/ARS.2008.2364
  9. Kandiah, N., Narasimhalu, K., Lee, J., & Chen, C. L. (2009). Differences exist in the cognitive profile of mild Alzheimer's disease and subcortical ischemic vascular dementia. Dement Geriatr Cogn Disord, 27(5), 399-403.
    DOI: 10.1159/000210387
  10. Kasiman, K., Eikelboom, J. W., Hankey, G. J., Lee, S. P., Lim, J. P., Lee, J. H., Chang, H. M., Wong, M. C., & Chen, C. P. (2009). Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in Singaporean stroke patients. Stroke, 40(6), 2209-2211.
    DOI: 10.1161/STROKEAHA.108.535237
  11. Kidwell, C. S., Lees, K. R., Muir, K. W., Chen, C., Davis, S. M., De Silva, D. A., Weir, C. J., Starkman, S., Alger, J. R., Saver, J. L., & Investigators, M. I. (2009). Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial. Stroke, 40(5), 1704-1709.
    DOI: 10.1161/STROKEAHA.108.537613
  12. Kong, K. H., Wee, S. K., Ng, C. Y., Chua, K., Chan, K. F., Venketasubramanian, N., & Chen, C. (2009). A double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional chinese medicine Neuroaid (MLC 601) in enhancing recovery after stroke (TIERS). Cerebrovasc Dis, 28(5), 514-521.
    DOI: 10.1159/000247001
  13. Lindley, R. I., Wang, J. J., Wong, M. C., Mitchell, P., Liew, G., Hand, P., Wardlaw, J., De Silva, D. A., Baker, M., Rochtchina, E., Chen, C., Hankey, G. J., Chang, H. M., Fung, V. S., Gomes, L., Wong, T. Y., Multi-Centre, R., & Stroke Study Collaborative, G. (2009). Retinal microvasculature in acute lacunar stroke: a cross-sectional study. Lancet Neurol, 8(7), 628-634.
    DOI: 10.1016/S1474-4422(09)70131-0
  14. Medhurst, A. D., Roberts, J. C., Lee, J., Chen, C. P., Brown, S. H., Roman, S., & Lai, M. K. (2009). Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice. Br J Pharmacol, 157(1), 130-138.
    DOI: 10.1111/j.1476-5381.2008.00075.x
  15. Narasimhalu, K., Ang, S., De Silva, D. A., Wong, M. C., Chang, H. M., Chia, K. S., Auchus, A. P., & Chen, C. (2009). Severity of CIND and MCI predict incidence of dementia in an ischemic stroke cohort. Neurology, 73(22), 1866-1872.
    DOI: 10.1212/WNL.0b013e3181c3fcb7
  16. Qiu, A., Fennema-Notestine, C., Dale, A. M., Miller, M. I., & Alzheimer's Disease Neuroimaging, I. (2009). Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroimage, 45(3), 656-661.
    DOI: 10.1016/j.neuroimage.2009.01.013
  17. Qiu, A., Taylor, W. D., Zhao, Z., MacFall, J. R., Miller, M. I., Key, C. R., Payne, M. E., Steffens, D. C., & Krishnan, K. R. (2009). APOE related hippocampal shape alteration in geriatric depression. Neuroimage, 44(3), 620-626.
    DOI: 10.1016/j.neuroimage.2008.10.010
  18. Sare, G. M., Gray, L. J., Wardlaw, J., Chen, C., Bath, P. M., & Investigators, E. T. (2009). Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial. Blood Press Monit, 14(1), 20-25.
    DOI: 10.1097/MBP.0b013e32831e30bd
  19. Tan, E. K., Lee, J., Chen, C. P., Teo, Y. Y., Zhao, Y., & Lee, W. L. (2009). SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese. Neurobiol Aging, 30(7), 1048-1051.
    DOI: 10.1016/j.neurobiolaging.2007.10.013
  20. Seet, R. C., & Chen, C. P. (2009). Optimizing antiplatelet therapy in high-risk patients with atrial fibrillation: insights from Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE A). Stroke, 40(12), 3883-3885.
    DOI: 10.1161/STROKEAHA.109.568576
  21. Tan, E. K., Lee, J., Chen, C. P., Wong, M. C., & Zhao, Y. (2009). Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiol Aging, 30(3), 501-502.
    DOI: 10.1016/j.neurobiolaging.2007.07.010
  22. Venketasubramanian, N., Chen, C. L., Gan, R. N., Chan, B. P., Chang, H. M., Tan, S. B., Picard, D., Navarro, J. C., Baroque, A. C., 2nd, Poungvarin, N., Donnan, G. A., Bousser, M. G., & Investigators, C. (2009). A double-blind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study). Int J Stroke, 4(1), 54-60.
    DOI: 10.1111/j.1747-4949.2009.00237.x

Year 2008 -

  1. Baker, M. L., Hand, P. J., Wang, J. J., & Wong, T. Y. (2008). Retinal signs and stroke: revisiting the link between the eye and brain. Stroke, 39(4), 1371-1379.
    DOI: 10.1161/STROKEAHA.107.496091
  2. De Silva, D., Woon, F. P., Chen, C., Chang, H. M., Kingwell, B., Cameron, J., & Wong, M. C. (2008). Profile and associations of central pulse wave velocity and central pulse pressure among ischemic stroke patients. Eur J Neurol, 15(2), 196-198.
    DOI: 10.1111/j.1468-1331.2007.02024.x
  3. De Silva, D. A., Lee, M. P., Wong, M. C., Chang, H. M., & Chen, C. L. (2008). Limb-shaking transient ischemic attack with distal micro-embolic signals and impaired cerebrovascular reactivity using transcranial Doppler. Ann Acad Med Singapore, 37(7), 619-620.
    DOI: 10.1016/S1873-9598(10)70022-3
  4. De Silva, D. A., Wong, T. Y., Chang, H. M., Ng, B. F., Tikellis, G., Saw, S. M., Woon, F. P., Chen, C. P., & Wong, M. C. (2008). Is routine retinal examination useful in patients with acute ischemic stroke? Stroke, 39(4), 1352-1354.
    DOI: 10.1161/STROKEAHA.107.495648
  5. De Silva, D. A., Woon, F. P., Gan, H. Y., Cameron, J., Kingwell, B., Koh, T. H., Chen, C., Chang, H. M., & Wong, M. C. (2008). Arterial stiffness, metabolic syndrome and inflammation amongst Asian ischaemic stroke patients. Eur J Neurol, 15(8), 872-875.
    DOI: 10.1111/j.1468-1331.2008.02208.x
  6. De Silva, D. A., Woon, F. P., Gan, H. Y., Chen, C., Chang, H. M., Cameron, J., Kingwell, B., & Wong, M. C. (2008). Arterial stiffness is associated with raised levels of the inflammatory marker erythrocyte sedimentation rate among ischaemic stroke patients. Intern Med J, 38(12), 918-920.
    DOI: 10.1111/j.1445-5994.2008.01811.x
  7. De Silva, D. A., Woon, F. P., Moe, K. T., Chen, C. L., Chang, H. M., & Wong, M. C. (2008). Concomitant coronary artery disease among Asian ischaemic stroke patients. Ann Acad Med Singapore, 37(7), 573- 575.
    PMID: 18695770
  8. Gan, R., Lambert, C., Lianting, J., Chan, E. S., Venketasubramanian, N., Chen, C., Chan, B. P., Samama, M. M., & Bousser, M. G. (2008). Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients. Cerebrovasc Dis, 25(5), 450- 456.
    DOI: 10.1159/000126919
  9. Lai, M. K., Tan, M. G., Kirvell, S., Hobbs, C., Lee, J., Esiri, M. M., Chen, C. P., & Francis, P. T. (2008). Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology. J Neural Transm (Vienna), 115(8), 1165-1172.
    DOI: 10.1007/s00702-008-0067-y
  10. Venketasubramanian, N., & Chen, C. L. (2008). Burden of stroke in Singapore. Int J Stroke, 3(1), 51- 54.
    DOI: 10.1111/j.1747-4949.2008.00181.x
  11. Marcos, B., Garcia-Alloza, M., Gil-Bea, F. J., Chuang, T. T., Francis, P. T., Chen, C. P., Tsang, S. W., Lai, M. K., & Ramirez, M. J. (2008). Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimers Dis, 14(1), 43-50.
    DOI: 10.3233/jad-2008-14104
  12. Narasimhalu, K., Lee, J., Auchus, A. P., & Chen, C. P. (2008). Improving detection of dementia in Asian patients with low education: combining the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly. Dement Geriatr Cogn Disord, 25(1), 17-22.
    DOI: 10.1159/000111128
  13. Sahadevan, S., Saw, S. M., Gao, W., Tan, L. C., Chin, J. J., Hong, C. Y., & Venketasubramanian, N. (2008). Ethnic differences in Singapore's dementia prevalence: the stroke, Parkinson's disease, epilepsy, and dementia in Singapore study. J Am Geriatr Soc, 56(11), 2061-2068.
    DOI: 10.1111/j.1532-5415.2008.01992.x
  14. Tsang, S. W., Francis, P. T., Esiri, M. M., Wong, P. T., Chen, C. P., & Lai, M. K. (2008). Loss of [3H]4- DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis. Psychopharmacology (Berl), 198(2), 251-259.
    DOI: 10.1007/s00213-008-1124-9
  15. Tsang, S. W., Vinters, H. V., Cummings, J. L., Wong, P. T., Chen, C. P., & Lai, M. K. (2008). Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease. Neurobiol Aging, 29(10), 1524-1532.
    DOI: 10.1016/j.neurobiolaging.2007.03.014
Information
 
Contact Us
+65 6601 5668
National University of Singapore
Yong Loo Lin School of Medicine,
Bldg MD3 #04-01,
16 Medical Drive,
Singapore 117600
This website best view with chrome version 90.x and above.
Copyright © 2021 Memory Ageing and Cognition Centre
Disclaimer & Terms Of Use | Website Designed by Elves Lab